Effect of Achillea wilhelmsii oral rinse on chemoradiotherapy induced oral mucositis in head and neck cancers

Evaluating the effect of Achillea wilhelmsii oral rinse on chemoradiotherapy induced oral mucositis in head and neck cancer patients

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20180516039682N3

Enrollment

Registered

2020-12-30

Start date

2021-01-20

Completion date

Unknown

Last updated

2021-01-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Oral mucositis (Stomatitis). Stomatitis and related lesions

Interventions

Intervention 1: Intervention group: From the first day of cancer treatment, the intervention group will use Achillea wilhelmsii mouthwash. Achillea wilhelmsii mouthwash will be prepared in the pharmac

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Patients with full consciousness Patients older than 18 years and younger than 60 years Patients with head and neck malignancies Patients undergoing chemotherapy and radiotherapy

Exclusion criteria

Exclusion criteria: Patients with oral mucositis Patients with any systemic diseases other than head and neck malignancies Patients with a history of allergy to Achillea wilhelmsii and medicinal plants Patients with a history of chemotherapy or radiotherapy Patients with xerostomia Use of drugs that reduce salivation Use of antibiotics, antifungals and systemic anti-inflammatory drugs Patients with malnutrition Smoking and alcohol consumption Use of dentures

Design outcomes

Primary

Measure	Time frame
Onset time of oral mucositis. Timepoint: Days 0, 7, 14, 21 and 28 after starting cancer treatment. Method of measurement: Clinical examination by a dentist based on World Health Organization oral mucositis grading scale.;Severity of oral mucositis. Timepoint: Days 0, 7, 14, 21 and 28 after starting cancer treatment. Method of measurement: Clinical examination by a dentist based on World Health Organization oral mucositis grading scale.	—

Measure

Time frame

Onset time of oral mucositis. Timepoint: Days 0, 7, 14, 21 and 28 after starting cancer treatment. Method of measurement: Clinical examination by a dentist based on World Health Organization oral mucositis grading scale.;Severity of oral mucositis. Timepoint: Days 0, 7, 14, 21 and 28 after starting cancer treatment. Method of measurement: Clinical examination by a dentist based on World Health Organization oral mucositis grading scale.

—

Secondary

Measure	Time frame
Patient's weight. Timepoint: Days 0, 7, 14, 21 and 28 after starting cancer treatment. Method of measurement: Using a digital scale.;Severity of oral pain. Timepoint: Days 0, 7, 14, 21 and 28 after starting cancer treatment. Method of measurement: Questionnaire.;Satisfaction with mouthwash. Timepoint: Days 0, 7, 14, 21 and 28 after starting cancer treatment. Method of measurement: Questionnaire.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Raheleh Akhavan Rasoolzadeh

Zanjan University of Medical Sciences

R.rasoolzadeh@zums.ac.ir+98 24 3314 8101

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026