multiple sclerosis. Multiple sclerosis
Conditions
Interventions
Intervention 1: Intervention group: 30 ptients with multiple sclerosis will received 600 mg N-acetylcysteine effervescent tablet ( Zambon Pharma Co, Switzerland) twice daily within 12 hours (1200 mg d
Sponsors
Ahvaz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Patients with multiple sclerosis more than 2 years EDSS = 4/5 Patients without current diagnosis of other inflammatory or autoimmune disease The age range is between 18-60 years Not taking depression or anxiety drugs Score of 10-30 (mild to moderate depression) from Beck Depression questionnaire in depression subscal and 15-25 (mild to moderate anxiety) from DASS21 questionnaire Tendency to participate in the study
Exclusion criteria
Exclusion criteria: Clinical relapses within 3 months before or during the study Pregnancy and lactation Cardiovascular diseases Patients with blood pressure disorders Liver and kidney disease Bronchospasm, asthma and any respiratory failure Gastric ulcer Bleeding and impaired blood coagulation Those who are allergic to NAC and any combination it contains, Taking antioxidants or NAC over the past 60 days Smoking, alcohol or drugs abuse Stressful events during the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Glutathione. Timepoint: The beginning of the study- The end of the study. Method of measurement: Spectrophotometry.;Malondialdehyde. Timepoint: The beginning of the study- The end of the study. Method of measurement: Spectrophotometry.;Total antioxidant capacity. Timepoint: The beginning of the study- The end of the study. Method of measurement: Spectrophotometry.;Nitric oxide. Timepoint: The beginning of the study- The end of the study. Method of measurement: Spectrophotometry.;Depression. Timepoint: The beginning of the study- The end of the study. Method of measurement: Beck questionnaire.;Anxiety. Timepoint: The beginning of the study- The end of the study. Method of measurement: DASS 21 questionnaire. | — |
Secondary
| Measure | Time frame |
|---|---|
| Body Mass Index. Timepoint: The beginning of the study- The end of the study. Method of measurement: Body weight / hight square (kg/m2).;Dietary intake. Timepoint: The beginning of the study- The end of the study. Method of measurement: Three-day record. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactGolsa Khalatbari Mohseni
Ahvaz University of Medical Sciences
Outcome results
None listed