Comparison of the effect of hydrodissection combined with corticosteroids and open surgery in the treatment of moderate and severe carpal tunnel syndrome

Comparison of the effect of hydrodissection combined with corticosteroids and open surgery in the treatment of moderate and severe carpal tunnel syndrome: A controlled clinical trial

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20180507039571N5

Enrollment

Registered

2025-03-26

Start date

2025-05-22

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Carpal tunnel syndrome. Carpal tunnel syndrome

Interventions

Intervention 1: Intervention group 1: Using an ultrasound device (ALPINION E-CUBE9 with 3-12 Mhz linear probe.ALPINION medical system.Seoul.South Korea), a hydrodissection injection of 5 cc of 5% dext

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients with moderate to severe Carpal tunnel syndrome based on electrodiagnostic testing Age above 18 Male and female gender Not receiving carpal tunnel injection treatment and physiotherapy and modalities in the last three months

Exclusion criteria

Exclusion criteria: Radiculopathy Plexopathy Motor neuron disease Peripheral neuropathy pregnancy Hand and bone joint deformity History of hand trauma Having uncontrolled systemic diseases, such as inflammatory joint diseases and uncontrolled diabetes Suffering from thenar atrophy and severe weakness of the palm muscles

Design outcomes

Primary

Measure	Time frame
Wrist pain score in carpal tunnel syndrome patients. Timepoint: Before the intervention and one, three, and six months after the completion of the intervention. Method of measurement: Using a visual analogue scale.;Severity of dysfunction. Timepoint: Before the intervention and one, three, and six months after the completion of the intervention. Method of measurement: Using the Boston carpal tunnel questionnaire (BCTQ).;Sensory and motor wave amplitude of the median nerve. Timepoint: Before and three months after the intervention. Method of measurement: Electrodiagnostic study.;Median nerve sensory and motor wave latency. Timepoint: Before and three months after the intervention. Method of measurement: Electrodiagnostic study.	—

Measure

Time frame

Wrist pain score in carpal tunnel syndrome patients. Timepoint: Before the intervention and one, three, and six months after the completion of the intervention. Method of measurement: Using a visual analogue scale.;Severity of dysfunction. Timepoint: Before the intervention and one, three, and six months after the completion of the intervention. Method of measurement: Using the Boston carpal tunnel questionnaire (BCTQ).;Sensory and motor wave amplitude of the median nerve. Timepoint: Before and three months after the intervention. Method of measurement: Electrodiagnostic study.;Median nerve sensory and motor wave latency. Timepoint: Before and three months after the intervention. Method of measurement: Electrodiagnostic study.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactShervin Ghaffari Hoseini

Esfahan University of Medical Sciences

shghaffari@yahoo.com+98 31 3611 5208

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026