Abdominal Hysterectomy.
Conditions
Interventions
Intervention 1: Intervention group: In the case group, immediately after the induction, Dexmedetomidine with a bolus dose of (1 µg/kg) during 15 minutes and infusion with a dose of (0.5 µg/kg) will be
Sponsors
Ahvaz University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
35 Years to 65 Years
Inclusion criteria
Inclusion criteria: Female candidate of Total Abdominal Hysterectomy (TAH) Body mass index (BMI): 18 to 40 kg/m2 American Society of Anesthesiologists (ASA) classification I , II
Exclusion criteria
Exclusion criteria: Allergic reaction to Dexmedetomidine History of Dexmedetomidine administration over the past week History of heart, lung, liver, and kidney diseases Patients with neurological or neuromuscular disorders Patients with anemia or bleeding disorders Consumption of Alcohol, narcotic and Antipsychotic medications Patients with diabetes
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Quantitative evaluation of C- Reactive Protein. Timepoint: 30 minutes before anesthesia induction (Before intervention), 1 hour after the start of operation, Immediately, 6 and 24 hours after the completion of the operation. Method of measurement: Blood test.;Quantitative evaluation of ESR. Timepoint: 30 minutes before anesthesia induction (Before intervention), 1 hour after the start of operation, Immediately, 6 and 24 hours after the completion of the operation. Method of measurement: Blood test.;Quantitative evaluation of Leukocytosis. Timepoint: 30 minutes before anesthesia induction (Before intervention), 1 hour after the start of operation, Immediately, 6 and 24 hours after the completion of the operation. Method of measurement: Blood test.;Quantitative evaluation of Blood Glucose. Timepoint: 30 minutes before anesthesia induction (Before intervention), 1 hour after the start of operation, Immediately, 6 and 24 hours after the completion of the operation. Method of measurement: Blood test.;Mean arterial pressure. Timepoint: Before anesthesia induction (Before intervention), after intubation, every 15 minutes until the end of the recovery period. Method of measurement: Gauge pressure.;Heart rate. Timepoint: Before anesthesia induction (Before intervention), after intubation, every 15 minutes until the end of the recovery period. Method of measurement: Electrocardiograph. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMaryam Derakhshani
Ahvaz University of Medical Sciences
Outcome results
None listed