Vaginal Atrophy.
Conditions
Interventions
Intervention 1: Intervention group: Centlla Asiatica Cream 1% , daily for 8 weeks as an applicator, produced in the laboratory of school of Pharmacy, Mashhad University of Medical Sciences, Mashhad,Ir
Sponsors
Mashhad University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
40 Years to 65 Years
Inclusion criteria
Inclusion criteria: Being Iranian and residence of Mashhad,Iran Married and Sexually active women age range of 40–65 years Having reading and writing skills Having amenorrhea for at least 12 months , or 6 months amenorrhea with FSH>40 or an endometrial thickness of 5 mm or less as determined by transvaginal ultrasonography Getting a score of = 65 on the visual analogue scale (VAS) and having at least one symptom of physical examination scale and a vaginal pH value > 5 and Vaginal maturation index(VMV) < 50
Exclusion criteria
Exclusion criteria: Current or suspected endometrial cancer Suspected genital cancer Reproductive system abnormalities Genital bleeding with unknown causes Use of anti hypertensive drugs Smoking or passing at least 3 months after smoking ceasation Vaginal infections Use of hormone replacement therapy 8 weeks before the study Use of foods containing 40 to 60 grams (about one tbsp) of phyto estrogen (such as red clover, flaxseeds and soy beans) in the past month Having conditions such as diabetes, chronic renal disease, arthritis, cardiovascular diseases, and active disease in the liver or gallbladder
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Vaginal pH. Timepoint: Beforeas well as 4 and 8 weeks after starting the intervention. Method of measurement: Merk PH-indicator strips.;Vaginal maturation value (VMV). Timepoint: Beforeas well as 4 and 8 weeks after starting the intervention. Method of measurement: Pathological examination.;Vaginal maturation index (VMI). Timepoint: Beforeas well as 4 and 8 weeks after starting the intervention. Method of measurement: Pathological examination. | — |
Secondary
| Measure | Time frame |
|---|---|
| Most bothersome symptom(MBS). Timepoint: Beforeas well as 4 and 8 weeks after starting the intervention. Method of measurement: Visual Analogue Scale.;Vaginal physical examination. Timepoint: Beforeas well as 4 and 8 weeks after starting the intervention. Method of measurement: physical examination scale. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMahnaz Rahmanpour
Mashhad University of Medical Sciences
Outcome results
None listed