Postoperative atrial fibrillation. Other postprocedural complications and disorders of the circulatory system, not elsewhere classified
Conditions
Interventions
Intervention 1: Intervention group: administration of a Metoprolol succin tablet 47.5 mg (Metohexal) and Potassium/Magnesium solution (10 cc of 15% potassium chloride solution of Shahid Ghazi company
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Atrial fibrillation after isolated coronary artery bypass graft surgery Continuation of atrial fibrillation rhythm for at least 15 minutes after initiation Serum Potassium level of 4-4.5 meq/L Serum Magnesium level of 4-4.5 meq/L Informed consent to participate in the study
Exclusion criteria
Exclusion criteria: Unstable hemodynamic (systolic blood pressure less than 90 mmHg) History of atrial fibrillation (persistent or paroxysmal) before surgery Serum creatinine level more than 1.4 mg/dl More than 12 hours have passed since the beginning of the atrial fibrillation rhythm Patients receiving packed cell Hemoglobin level less than 7 g/L Spontaneous cardioversion before randomization Patients receiving Inotrope
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cardioversion of atrial fibrillation to sinus rhythm within the first 6 hour. Timepoint: From the start of the intervention until 6 hours later. Method of measurement: Cardiac rhythm monitoring. | — |
Secondary
| Measure | Time frame |
|---|---|
| Time required to convert atrial fibrillation rhythm to sinus rhythm (in the first 6 hours). Timepoint: From the start of the intervention until 6 hours later. Method of measurement: Cardiac rhythm monitoring.;Heart rate less than 110 beats per minute during the first 3 hours of treatment. Timepoint: From the start of the intervention until 3 hours later. Method of measurement: Cardiac rhythm monitoring.;The rate of recurrence of atrial fibrillation in the first 48 hours after the restoration of sinus rhythm. Timepoint: From the time of sinus rhythm restoration to 48 hours later. Method of measurement: Cardiac rhythm monitoring.;The rate of sinus rhythm restoration within 24 hours of Amiodarone initiation. Timepoint: From the initiation of Amiodarone infusion to 24 hours later. Method of measurement: Cardiac rhythm monitoring.;The cumulative dose of Amiodarone required to restore sinus rhythm. Timepoint: From the initiation of Amiodarone infusion to restoration of sinus rhythm. Method of measurement: The total amount of Amiodarone that is prescribed until restoration of sinus rhythm.;The time required to restore the sinus rhythm after initiation of Amiodarone infusion. Timepoint: From the initiation of Amiodarone infusion to restoration of sinus rhythm. Method of measurement: Total sum of time, in minutes, from the initiation of Amiodarone infusion to restoration of sinus rhythm.;The rate of bradycardia (heart rate less than 60/minute) in the first 6 hours after starting intervention. Timepoint: From the start of the intervention until 6 hours later. Method of measurement: Cardiac rhythm monitoring.;The rate of systolic blood pressure less than 90 mm Hg in the first 6 hours after starting intervention. Timepoint: From the start of the intervention until 6 hours later. Method of measurement: Blood pressure monitoring. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactFarzad Masoudkabir
Tehran University of Medical Sciences
Outcome results
None listed