Advanced atrioventricular block following heart valve surgery. Atrioventricular and left bundle-branch block
Conditions
Interventions
Intervention 1: Intervention group: Administration of intravenous dexamethasone with dose of 0.4 mg per kg (maximum dose of 35 mg per day) in divided schedule for 3 consecutive days. All patients incl
Sponsors
Tehran Heart Center
Eligibility
Sex/Gender
All
Age
15 Years to 80 Years
Inclusion criteria
Inclusion criteria: Presence of advanced atrioventricular block following heart valve surgery including valve replacement or repair with or without CABG Written documented informed consent
Exclusion criteria
Exclusion criteria: Exclusion of patients having cardiac pacemakers or intracardiac defibrilator-cardiovertor or CRT Exclusion of subjects having prior advanced AV block with underlying congenital or acquired etiologies or known brady-arrhythmia Exclusion of patients with acute or recent myocardial infarction or CPR during last week (or survivors of aborted sudden cardiac death) Exclusion of diabetics with uncontrolled hyperglycemia ( BS>200 in 2 or more measurements out of 4 samples during last 24 hours or HbA1C>9, ketoacidosis or hyperglycemic hyperosmolar state) Exclusion of patients with active infections Exclusion of patients with immune deficiency disorders including malignancies and HIV-AIDS,.... Exclusion of patients with prior history of hypersensitivity reactions to steroids Exclusion of patients with persistent or permanent atrial fibrillation (AF for more than 24 hours except transient or paroxysmal cases)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Frequency or recovery of AV block. Timepoint: 5days. Method of measurement: Duration of AV block in hours and percentage of recovery after 5 days. | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence rate of of PPM implantation. Timepoint: One month. Method of measurement: Observation and follow-up.Percentage of patients in each group who ultimately undergone PPM implantation. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactFarzad masoud kabir
Tehran University of Medical Sciences
Outcome results
None listed