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Study of the effect of selenium on myocardial protection

Effect of selenium added to the cardioplegic solution on cardiac protection in coronary artery bypass grafting surgeries And the comparison with the control group

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20180422039383N1
Enrollment
66
Registered
2019-01-26
Start date
2017-06-21
Completion date
Unknown
Last updated
2019-02-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary Artery Bypass Graft Surgery.

Interventions

Intervention 1: Intervention group: Adding 1000 microgram Selenium (Sodium selenite) to Cardioplegic Solution. The cardiopulmonary solution is then injected into the coronary arteries. Intervention 2:

Sponsors

Shiraz University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
35 Years to 79 Years

Inclusion criteria

Inclusion criteria: Company satisfaction in research design EF more than 30% Age over 35 and under 80 Patients referred to the heart surgery room for CABG operation in government hospitals affiliated to Shiraz University of Medical Sciences.

Exclusion criteria

Exclusion criteria: Combination and redo surgery History of recent infarction (less than a week) pregnancy High troponin level (greater than 3µgl / lit /)

Design outcomes

Primary

MeasureTime frame
Cardiac Troponin marker: The most specific marker for heart damage. Timepoint: Troponin: at pre-operative intervals, immediately after surgery, 6 and 24 hours after surgery. Method of measurement: Troponin: Vidas Laboratory tool.;Arrhythmia :It is called a disturbance in the normal rhythm of the heart and a symptom of a disorder in the normal functioning of the heart. Timepoint: From the de-clamping of aorta until the patient is delivered to the ICU. Method of measurement: Monitoring of arrhythmias using cardiac monitoring and eye care.;Drug use and DC shock: The use of medication and DC shock indicates the severity of the risk and the risk of arrhythmia, which can be studied by comparing it in two groups. Timepoint: From the de-clamping of aorta until the patient is delivered to the ICU. Method of measurement: Through observation and review of the doctor's order in the patient file documents.;Intra Aortic Ballon Pump : In a condition, the contractile power of the heart is not sufficient is used and increases the contractile power of the heart. Timepoint: After weaning of cardiopulmonary pump. Method of measurement: Doctor's order.Patient File Documentation.

Secondary

MeasureTime frame
Blood Pressure. Timepoint: Before the operation, During the Cardiopulmonary Bypass, after cardiopulmonary bypass. Method of measurement: Arterial Line.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMasih Shafa

Shiraz University of Medical Sciences

masooda1361@gmail.com+98 71 3230 5410

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026