comparision of efficacy of intradermal tranxamic acid injection with fractional Q-Switch Nd-yag laser for melasma treatment

Assessing the effectiveness, safety and patient satisfaction of intradermal tranxamic acid injection in comparision with fractional Q-Switch Nd-yag laser for melasma treatment

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20180418039349N1

Enrollment

Registered

2018-06-27

Start date

2018-05-22

Completion date

Unknown

Last updated

2018-07-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

melasma. Chloasma

Interventions

Intervention 1: In the group treated with tranxamic acid: Prior to treatment, local anesthetic treatment, a 2.5% lidocaine hydrochloride plus 2.5% prilocaine for 20 to 20 minutes will be applied on si

Eligibility

Sex/Gender

Female

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: women over the age of 18 moderate to severe melasma

Exclusion criteria

Exclusion criteria: pregnancy lactation patients who have received contraceptive drugs in the last 12 months Patients with hemorrhagic or anticoagulant abnormalities anticoagulant dug using receiving another treatment for melasma at the same time receive topical treatment for melasma for example hydroquinone one month before treatment.

Design outcomes

Primary

Measure	Time frame
Melanin index. Timepoint: before treatment session 8,12. three moth after treatment. Method of measurement: multi probe adaptor.;Skin lightening. Timepoint: before treatment session 8,12. three moth after treatment. Method of measurement: colorimeter.;Modified MASI score. Timepoint: before treatment session 4,8,12. three moth after treatment. Method of measurement: clinicaly by the physician. face is divided into four parts: forehead, right malar, left malar and chin , and the degree of severity of melasma is measured based on three criteria. The percentage of area ( from zero to six points) and the degree of darkness are also categorized from zero to four points.;Patient satisffaction. Timepoint: in the end of study. Method of measurement: The patient's own assessment of the improvement of melasma is based on four points. Exercise: Improvement of more than 75% / fine: 75-51% Fairly good: 50-26% / Slight: 25-0%.;Graphy. Timepoint: before treatment session 4,8,12. three moth after treatment. Method of measurement: visiofase.	—

Measure

Time frame

Melanin index. Timepoint: before treatment session 8,12. three moth after treatment. Method of measurement: multi probe adaptor.;Skin lightening. Timepoint: before treatment session 8,12. three moth after treatment. Method of measurement: colorimeter.;Modified MASI score. Timepoint: before treatment session 4,8,12. three moth after treatment. Method of measurement: clinicaly by the physician. face is divided into four parts: forehead, right malar, left malar and chin , and the degree of severity of melasma is measured based on three criteria. The percentage of area ( from zero to six points) and the degree of darkness are also categorized from zero to four points.;Patient satisffaction. Timepoint: in the end of study. Method of measurement: The patient's own assessment of the improvement of melasma is based on four points. Exercise: Improvement of more than 75% / fine: 75-51% Fairly good: 50-26% / Slight: 25-0%.;Graphy. Timepoint: before treatment session 4,8,12. three moth after treatment. Method of measurement: visiofase.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactNahid Nikkhah

Tehran University of Medical Sciences

nahid_nickhah@yahoo.com+98 21 2221 5558

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026