Recurrent Implantation failure in IVF.
Conditions
Interventions
Intervention group: Intervention group are received Nifedipine Tablet 20 mg for 1/2 hr before embryo transfer.
Sponsors
Babol University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1.Women 18-40 yr with BMI= 100/60, 3. FSH <14mli/IU. 4. abnormal uterus in HSG or hystroscopy. 5. who do not contraindicate the use of nifedipine, such as heart and liver 6. Patients who do not have a history of irregular heart rate or who do not use hypotention medication.
Exclusion criteria
Exclusion criteria: Patients who have been taking medication with nifedipine over a month have interfered with drugs such as benzodiazepines, flecainide, imipramine, propafenone, azole antifungals, cimetidine, cyclosporine, erythromycin, quinidine, terfenadine, warfarin and theophylline. 2.Those who have blood pressure of 60/100 (mmHg) or less before embryo transfer
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pregnancy rate( hCG>31IU/LI) 12 days following embryo transfer. Timepoint: 12 days following embryo transfer. Method of measurement: Blood test, BHCG. | — |
Secondary
| Measure | Time frame |
|---|---|
| Implantation rate: Gestational sac. Timepoint: in 6 weeks after pregnancy. Method of measurement: vaginal sonography.;Clinical pregnancy, Fetal heart rate observation. Timepoint: 6-8 after pregnancy. Method of measurement: vaginal sonography.;Spontaneous abortion. Timepoint: before 20 week pregnancy. Method of measurement: vaginal sonography.;Complications of pregnancy and infant including multiple or ectopic pregnancy, spotting and vaginal bleeding. Timepoint: in 3 months pregnancy. Method of measurement: vaginal sonography. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactFatemeh
Babol University of Medical Sciences
Outcome results
None listed