Increased resistance of the uterine artery in color Doppler ultrasound in pregnant women. O28.3
Conditions
Interventions
Intervention 1: Intervention group: In the intervention group, along with daily intake of 80 mg aspirin from Karn Pharmaceuticals, the participant will consume 1000 mg L-arginine capsules from Karn Ph
Sponsors
Arak University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: Pregnant women with increased uterine artery resistance, presenting to Talaghani Hospital in Arak, where their elevated uterine artery blood pressure is diagnosed by specialists in obstetrics and gynecology and Doppler ultrasound between weeks 12-24 Consent to participate in the study Not having a specific diet regimen and not using lipid-lowering or blood sugar-lowering medications No sensitivity to L-arginine (including any drug allergies to this supplement)
Exclusion criteria
Exclusion criteria: The patient does not wish to continue cooperation or medication usage, and will not attend for ultrasound or visits During the study, signs and symptoms of drug hypersensitivity (including any drug allergies to this supplement) to L-arginine may manifest in pregnant women
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Uterine artery resistance index. Timepoint: In two time intervals: the first interval from the beginning of the study (before starting L-arginine supplement intake) between weeks 12 to 24 of pregnancy, and the second interval 6 weeks after L-arginine supplement consumption. Method of measurement: Trans Abdominal color Doppler ultrasound.;Uterine artery pulsatility index. Timepoint: In two time intervals: the first interval from the beginning of the study (before starting L-arginine supplement intake) between weeks 12 to 24 of pregnancy, and the second interval 6 weeks after L-arginine supplement consumption. Method of measurement: Trans Abdominal color Doppler ultrasound. | — |
Secondary
| Measure | Time frame |
|---|---|
| Birth weight. Timepoint: At birth. Method of measurement: Scale.;APGAR score at birth (first and fifth minute). Timepoint: One and five minutes after birth of the newborn. Method of measurement: According to the obstetrician or pediatric specialist's opinion.;Gestational age at delivery. Timepoint: At the time of delivery. Method of measurement: Pregnancy week based on first day of the last menstrual period (LMP).;Preeclampsia. Timepoint: Evaluation of blood pressure during weekly follow-up visits after enrollment in the study, and in case of blood pressure exceeding 140/90, assessment of other signs and symptoms of preeclampsia. Method of measurement: Obstetrician's visit.;Occurrence of intrauterine growth restriction (IUGR). Timepoint: From gestational age of 24 weeks and then every two weeks. Method of measurement: Trans Abdominal biometry ultrasound. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactShiva Bahrami
Arak University of Medical Sciences
Outcome results
None listed