the effect of rosuvastatin gel on healing of extracted tooth

investigating the effect of advanced platelet-rich fibrin and rosuvastatin gel on the healing condition of extracted tooth socket

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20180416039327N3

Enrollment

Registered

2020-07-27

Start date

2020-07-18

Completion date

Unknown

Last updated

2020-08-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Loss of teeth due to extraction. Loss of teeth due to extraction

Interventions

Intervention 1: Control group: spontaneous healing of extracted tooth socket that will not receive any special intervention. Intervention 2: Intervention group: Advanced platelet-rich fibrin in extra

Eligibility

Sex/Gender

All

Age

20 Years to 60 Years

Inclusion criteria

Inclusion criteria: The patient with not restorable tooth or crown, a root fracture, extensive decay Residual roots without apical lesions Soft tissue and buccal bone plate at normal distance from CEJ Atraumatic tooth extraction People who are in complete health status

Exclusion criteria

Exclusion criteria: smokers Pregnant and lactating women History of radiation therapy and chemotherapy Sensitivity to statin drugs Socket Type II or III Injecting bisphosphonate Adjacent to the toothless area

Design outcomes

Primary

Measure	Time frame
Pain. Timepoint: 6, 24 and 48 hours post surgery. Method of measurement: Using VAS which is reported as 0 (No pain) to 10 (Severe pain).;The healing of soft tissue of extracted tooth socket. Timepoint: at baseline and 10 days after the surgery. Method of measurement: Landry index is recorded from 1 to 5 based on erythema, granulation tissue, bleeding in palpation and incision line.;The healing of hard tissue of extracted tooth socket. Timepoint: at baseline, 4 and 12 weeks after surgery. Method of measurement: Amount of bone trabecule formed in the extracted tooth socket is measured in parallel peri-apical radiography using ImageJ software.	—

Measure

Time frame

Pain. Timepoint: 6, 24 and 48 hours post surgery. Method of measurement: Using VAS which is reported as 0 (No pain) to 10 (Severe pain).;The healing of soft tissue of extracted tooth socket. Timepoint: at baseline and 10 days after the surgery. Method of measurement: Landry index is recorded from 1 to 5 based on erythema, granulation tissue, bleeding in palpation and incision line.;The healing of hard tissue of extracted tooth socket. Timepoint: at baseline, 4 and 12 weeks after surgery. Method of measurement: Amount of bone trabecule formed in the extracted tooth socket is measured in parallel peri-apical radiography using ImageJ software.

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Secondary

Measure	Time frame
Bone trabeculae size. Timepoint: 3 months after the surgery. Method of measurement: By histo-pathology evaluation.;Percentage of mineralized bone. Timepoint: 3 months after the surgery. Method of measurement: By histo-pathology evaluation.;Percentage of Osteoidal tissue. Timepoint: 3 months after the surgery. Method of measurement: By histo-pathology evaluation.;Bucco-lingual width of extracted tooth socket. Timepoint: baseline and 3 months after the surgery. Method of measurement: Using a probe this index is measured in millimeter from a reference point on the adjacent tooth.;Mesio-distal width of extracted tooth socket. Timepoint: baseline and 3 months after the surgery. Method of measurement: Using a probe this index is measured in millimeter from a reference point on the adjacent tooth.;Height of extracted tooth socket. Timepoint: baseline and 3 months after the surgery. Method of measurement: Using a probe this index is measured in millimeter from a reference point on the adjacent tooth.;Thickness of buccal wall of extracted tooth socket. Timepoint: baseline and 3 months after the surgery. Method of measurement: Using a Colis.	—

Measure

Time frame

Bone trabeculae size. Timepoint: 3 months after the surgery. Method of measurement: By histo-pathology evaluation.;Percentage of mineralized bone. Timepoint: 3 months after the surgery. Method of measurement: By histo-pathology evaluation.;Percentage of Osteoidal tissue. Timepoint: 3 months after the surgery. Method of measurement: By histo-pathology evaluation.;Bucco-lingual width of extracted tooth socket. Timepoint: baseline and 3 months after the surgery. Method of measurement: Using a probe this index is measured in millimeter from a reference point on the adjacent tooth.;Mesio-distal width of extracted tooth socket. Timepoint: baseline and 3 months after the surgery. Method of measurement: Using a probe this index is measured in millimeter from a reference point on the adjacent tooth.;Height of extracted tooth socket. Timepoint: baseline and 3 months after the surgery. Method of measurement: Using a probe this index is measured in millimeter from a reference point on the adjacent tooth.;Thickness of buccal wall of extracted tooth socket. Timepoint: baseline and 3 months after the surgery. Method of measurement: Using a Colis.

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Countries

Iran (Islamic Republic of)

Contacts

Public Contactfahimeh khaqani

Rasht University of Medical Sciences

khaqanif@yahoo.com+98 13 3332 0060

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026