Skip to content

The effect of dexmedetomidine on reducing the incidence of cough after extubation

Comparison of safety and efficacy of two doses of Dexmedetomidine in reducing the incidence of cough after endotracheal tube removal in a patient undergoing elective surgery

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20180416039326N19
Enrollment
540
Registered
2021-09-16
Start date
2021-04-21
Completion date
Unknown
Last updated
2021-11-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Tracheal Extubation.

Interventions

Intervention 1: Intervention group 1: In this group, the syringe containing dexmedetomidine (from Behestan Daroo company) is diluted to 1mcg / kg in 100 ml of normal saline and infused into the patien

Sponsors

Esfahan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Patients who are candidates for elective surgery Age range is 18-60 years and with ASA class 1 and 2. Patient consent to participate in the study

Exclusion criteria

Exclusion criteria: History of allergy to Alpha adrenergic drugs Liver patients Patients with a history of Bradycardia Vascular problems Hypotension Vasodilator use Hypovolemia People who are at risk for increased intracranial pressure or intraocular pressure Addicted people or Smokers People with asthma Patients with a history of airway infection or history of airway surgery.

Design outcomes

Primary

MeasureTime frame
Systolic bBlood Pressure. Timepoint: Before Extubation and 1, 3, 5 and 10 minutes after extubation. Method of measurement: Barometer.;Diastolic blood pressure. Timepoint: Before Extubation and 1, 3, 5 and 10 minutes after extubation. Method of measurement: Barometer.;Pulse rate. Timepoint: Before Extubation and 1, 3, 5 and 10 minutes after extubation. Method of measurement: Pulse oximetry.;Oxygen saturation percentage. Timepoint: Before Extubation and 1, 3, 5 and 10 minutes after extubation. Method of measurement: Pulse oximetry.;Mean arterial pressure. Timepoint: Before Extubation and 1, 3, 5 and 10 minutes after extubation. Method of measurement: Barometer.;Cough. Timepoint: 1, 3, 5 and 10 minutes after the end of the extubation. Method of measurement: View.

Secondary

MeasureTime frame
Duration of staying in recovery. Timepoint: Based on minutes from arrival to reaching the modified aldrete score of 9. Method of measurement: Information collection form.;Adverse airway response. Timepoint: During the time of staying in recovery. Method of measurement: Information collection form.;Hemodynamic complications. Timepoint: During the time of staying in recovery. Method of measurement: Information collection form.;Duration of extubation. Timepoint: Based on minutes from the time of discontinuing anesthetic to the time of extubation. Method of measurement: Information collection form.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactHamidreza Shetabi

Esfahan University of Medical Sciences

hamidshetabi@med.mui.ac.ir+980313622020

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026