Tracheal Extubation.
Conditions
Interventions
Intervention 1: Intervention group 1: In this group, a syringe containing labetalol (0.1 mg / kg diluted with 0.9% saline to a volume of 5 ml) will be injected. Intervention 2: Intervention group 2: I
Sponsors
Esfahan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
20 Years to 60 Years
Inclusion criteria
Inclusion criteria: Normotensive patients who are candidates for elective surgery less than two hours under general anesthesia requiring endotracheal intubation Age between 20 to 60 years ASA one and two Informed consent to participate in the study Weight 55 to 85 kilogram
Exclusion criteria
Exclusion criteria: Pregnant women Diabetic patients Patients with uncontrolled underlying cardiovascular disease Baseline heart rate less than 60 beats per minute and systolic blood pressure less than 90 mmHg Patients with cerebrovascular diseases Contraindication of the use of study medicines Known allergy to anesthetics in the study Opioid abuse Taking medicines with cardiovascular effects
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Systolic blood pressure. Timepoint: Before extubation and 1, 3, 5 and 10 minutes after extubation. Method of measurement: Barometer.;Diastolic blood pressure. Timepoint: Before extubation and 1, 3, 5 and 10 minutes after extubation. Method of measurement: Barometer.;Pulse rate. Timepoint: Before extubation and 1, 3, 5 and 10 minutes after extubation. Method of measurement: Pulse oximetry.;Oxygen saturation percentage. Timepoint: Before extubation and 1, 3, 5 and 10 minutes after extubation. Method of measurement: Pulse oximetry.;Mean arterial pressure. Timepoint: Before extubation and 1, 3, 5 and 10 minutes after extubation. Method of measurement: Barometer. | — |
Secondary
| Measure | Time frame |
|---|---|
| Duration of staying in recovery. Timepoint: Based on minutes from arrival to reaching the modified aldrete score of 9. Method of measurement: Information collection form.;Adverse airway response. Timepoint: During the time of staying in recovery. Method of measurement: Information collection form.;Hemodynamic complications. Timepoint: During the time of staying in recovery. Method of measurement: Information collection form.;Duration of extubation. Timepoint: Based on minutes from the time of discontinuing anesthetics to the time of extubation. Method of measurement: Information collection form. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactHamidreza Shetabi
Esfahan University of Medical Sciences
Outcome results
None listed