Effect of intranasal dexamethasone on prevention of postoperative nausea and vomiting in hysterectomy

Comparative study of the effect of intranasal dexamethasone on prevention of postoperative nausea and vomiting in hysterectomy

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20180416039326N13

Enrollment

Registered

2020-06-15

Start date

2020-06-14

Completion date

Unknown

Last updated

2020-07-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative Nausea and Vomiting. Nausea and Vomiting

Interventions

Intervention 1: Intervention group: After receiving 10ml/kg of ringer lactate and pre-oxygenation for patients, the same anesthetic induction was performed including Fentanyl 2mcg / kg, Propofol 2 mg

Eligibility

Sex/Gender

Female

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Women older than 18 years American society of anesthesiologists(ASA) physical status classification 1 or 2 Filled informed consent form Hysterectomy under general anesthesia

Exclusion criteria

Exclusion criteria: Patient with sever and uncontroled cardiovascular ? renal ? liver and chronic lung diseases Systemic fungal infection Contraindication for dexamethasone Taking antiemetic and analgesics drugs during last 24 hours before surgery Pregnant women Menstural period Patients with motion sickness and GI problems and history of postoperative nausea and vomiting Patients with History of psycologic problem and Parkinson disease History of chemotherapy

Design outcomes

Primary

Measure	Time frame
Incidence of nausea. Timepoint: At recovery (every 10min or having symptom) and 2 and 12 and 24 hours after surgery. Method of measurement: Visual Analogue Scale.;Score of nausea. Timepoint: At recovery (every 10min or having symptom) and 2 and 12 and 24 hours after surgery. Method of measurement: Visual Analogue Scale.;Incidence of vomiting. Timepoint: At recovery (every 10min or having symptom) and 2 and 12 and 24 hours after surgery. Method of measurement: scoring system for vomiting.;Score of vomiting. Timepoint: At recovery (every 10min or having symptom) and 2 and 12 and 24 hours after surgery. Method of measurement: Scoring system for vomiting.;Score of pain. Timepoint: At recovery (every 10min or having symptom) and 2 and 12 and 24 hours after surgery. Method of measurement: Visual Analogue Scale.;First time using anti emetic drug. Timepoint: 24 hours after entering recovery. Method of measurement: minute.;Total dose of anti emetic. Timepoint: 24 hours after entering recovery. Method of measurement: file.;Frequency of using anti emetic drug. Timepoint: 24 hours after entering recovery. Method of measurement: file.;Extubation time. Timepoint: After Extubation. Method of measurement: minute.;Length of stay in recovery. Timepoint: After exiting recovery. Method of measurement: minute.;Patient satisfaction score. Timepoint: 24 hours after entering recovery. Method of measurement: Likert scale.;Beginning time of using liquid foods. Timepoint: after using liquid foods. Method of measurement: minute.;Beginning time of using solid foods. Timepoint: after using solid foods. Method of measurement: minute.;Length of stay in hospital. Timepoint: After exiting hospital. Method of measurement: day.	—

Measure

Time frame

Incidence of nausea. Timepoint: At recovery (every 10min or having symptom) and 2 and 12 and 24 hours after surgery. Method of measurement: Visual Analogue Scale.;Score of nausea. Timepoint: At recovery (every 10min or having symptom) and 2 and 12 and 24 hours after surgery. Method of measurement: Visual Analogue Scale.;Incidence of vomiting. Timepoint: At recovery (every 10min or having symptom) and 2 and 12 and 24 hours after surgery. Method of measurement: scoring system for vomiting.;Score of vomiting. Timepoint: At recovery (every 10min or having symptom) and 2 and 12 and 24 hours after surgery. Method of measurement: Scoring system for vomiting.;Score of pain. Timepoint: At recovery (every 10min or having symptom) and 2 and 12 and 24 hours after surgery. Method of measurement: Visual Analogue Scale.;First time using anti emetic drug. Timepoint: 24 hours after entering recovery. Method of measurement: minute.;Total dose of anti emetic. Timepoint: 24 hours after entering recovery. Method of measurement: file.;Frequency of using anti emetic drug. Timepoint: 24 hours after entering recovery. Method of measurement: file.;Extubation time. Timepoint: After Extubation. Method of measurement: minute.;Length of stay in recovery. Timepoint: After exiting recovery. Method of measurement: minute.;Patient satisfaction score. Timepoint: 24 hours after entering recovery. Method of measurement: Likert scale.;Beginning time of using liquid foods. Timepoint: after using liquid foods. Method of measurement: minute.;Beginning time of using solid foods. Timepoint: after using solid foods. Method of measurement: minute.;Length of stay in hospital. Timepoint: After exiting hospital. Method of measurement: day.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactHamidreza Shetabi

Esfahan University of Medical Sciences

hamidshetabi@med.mui.ac.ir+98 31 3620 1818

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026