Oral Candidiasis. Candidal stomatitis/Oral thrush
Conditions
Interventions
Intervention 1: Intervention group: nanocurcumin soft gel (containing 80 mg curcumin) are administrated orally once daily. Intervention 2: Control group: The control group: placebo tablets are adminis
Sponsors
Mashhad University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: the minimum age of 18 years, presence of head and neck cancer, radiation dose of 50-70 Gy, at least 50% of patient’s oral cavity in the field of radiation and patient satisfaction.
Exclusion criteria
Exclusion criteria: previous history of radiation therapy, patient dissatisfaction, history of allergy to turmeric, , in case of any oral lesions or complication resulting from radiation therapy other than candidiasis and mucositis, use of systemic or topical antifungal drugs for any reason, pregnancy or breastfeeding periods in women under treatment, presence of local and systemic conditions predisposing for candidiasis, such as the application of inhaled and topical steroids, presence of hyperkeratosis, use of immunosuppressive drugs, history of systemic antibiotic usage over the previous 2 weeks, the presence of CFU above 400/ml in the first culture or clinical evidence based on the presence of oral candidiasis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ccurrence of oral candidiasis. Timepoint: The first day of radiotherapy before radiation, every week until the end of the study. Method of measurement: Clinical examinations of oral lesion.;Candidate colony count in ml (colony forming unit = CFU). Timepoint: before the study, in the third week and the final week of radiotherapy. Method of measurement: Cultivation of oral lesions. | — |
Secondary
| Measure | Time frame |
|---|---|
| Type of oral Candidiasis. Timepoint: before the study, in the third week and the final week of radiotherapy. Method of measurement: germ tube test and cultivation of oral lesions. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSedigheh Modarres Mousavy
Mashhad University of Medical Sciences
Outcome results
None listed