oral mucositis. Stomatitis and related lesions
Conditions
Interventions
Intervention 1: Intervention group:80 mg/d oral curcumin (1 capsule of SinaCurcumin® 80 per day), during radiotherapy (6 weeks). Each soft gel of SinaCurcumin® contains 80 mg of curcumin in the form o
Sponsors
Mashhad University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Inclusion criteria were the following: minimum age of 18 years, presence of head and neck cancer, radiationtherapy of 50 Gy or greater, at least 50% of patient’s oral cavity in the field of radiation, and willing to be a part of the study and sign the informed consent..
Exclusion criteria
Exclusion criteria: Exclusion criteria were the following: the history of previous radiation therapy or chemotherapy, chemotherapy protocol in addition to radiotherapy, any allergy to condiments, especially “Turmeric root”, having a pre-existing oral disease such as an active oral infection or an oral ulceration.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The effect of curcumin on severity of mucositis. Timepoint: Before the initiation of radiotherapy and then on days 7, 14, 21, 28, 35 and 42 of the radiotherapy course. Method of measurement: the National Cancer Institute Common Toxicity Criteria version 2 scale (NCI CTC v.2). | — |
Secondary
| Measure | Time frame |
|---|---|
| The effect of curcumin on the onset of mucositis. Timepoint: Before the initiation of radiotherapy and then on days 7, 14, 21, 28, 35 and 42 of the radiotherapy course. Method of measurement: the National Cancer Institute Common Toxicity Criteria version 2 scale (NCI CTC v.2). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAla Ghazi
Mashhad University of Medical Sciences
Outcome results
None listed