Nonalcoholic fatty liver. Fatty (change of) liver, not elsewhere classified
Conditions
Interventions
Intervention 1: Intervention group: Consumption of chitosan (dose of supplements: 500 miligram) twice a day (one before lunch and one before dinner) for 12 weeks. Chitosan supplements are provided by
Sponsors
Ahvaz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Aged between 18-65 years (both genders) Diagnosis of nonalcoholic fatty liver disease by ultrasound Willingness to participate No allergies to seafood
Exclusion criteria
Exclusion criteria: Suffering from viral hepatitis, liver cirrhosis, Wilson's disease, acute fatty liver, hepatocellular carcinoma, hypothyroidism, lipodystrophy, diseases that involves bile ducts History of chronic liver disease History of significant weight loss (more than 10% of body weight during 6 months ago) or weight loss surgery History of antioxidant supplementation, omega 3 and milk thistle during 6 months ago History of liver damaging drugs History of cardiovascular History of renal disease Alcohol consumption more than 20 gram per day Pregnancy Lactation Menopause Energy consumption less than 800 or more than 4200 kilocalorie per day
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Glycated hemoglobin A1c. Timepoint: Before the intervention and twelve weeks after. Method of measurement: Spectrophotometry.;Fasting blood glucose. Timepoint: Before the intervention and twelve weeks after. Method of measurement: Enzymatic method.;Plasma insulin. Timepoint: Before the intervention and twelve weeks after. Method of measurement: Calorimetry.;Serum adiponectin. Timepoint: Before the intervention and twelve weeks after. Method of measurement: ELISA.;Serum leptin. Timepoint: Before the intervention and twelve weeks after. Method of measurement: ELISA.;Interleukin-6. Timepoint: Before the intervention and twelve weeks after. Method of measurement: ELISA.;TNF-alpha. Timepoint: Before the intervention and twelve weeks after. Method of measurement: ELISA.;Serum total antioxidant capacity (TAC). Timepoint: Before the intervention and twelve weeks after. Method of measurement: ELISA.;High Density Lipoprotein (HDL). Timepoint: Before the intervention and twelve weeks after. Method of measurement: Enzymatic method.;Low Density Lipoprotein (LDL). Timepoint: Before the intervention and twelve weeks after. Method of measurement: Enzymatic method.;Total cholesterol. Timepoint: Before the intervention and twelve weeks after. Method of measurement: Enzymatic method.;Triglyceride. Timepoint: Before the intervention and twelve weeks after. Method of measurement: Enzymatic method. | — |
Secondary
| Measure | Time frame |
|---|---|
| Weight. Timepoint: Before the intervention and twelve weeks after. Method of measurement: Scale (seca).;Body Mass Index (BMI). Timepoint: Before the intervention and twelve weeks after. Method of measurement: Weight (kg) divided to height square.;Visceral Adiposity Index. Timepoint: Before the intervention and twelve weeks after. Method of measurement: Formula based on these variables: BMI, waist circumference, HDL-C and triglyceride (TG).;Aspartate aminotransferase (AST). Timepoint: Before the intervention and twelve weeks after. Method of measurement: Enzymatic method.;Alanine aminotransferase (ALT). Timepoint: Before the intervention and twelve weeks after. Method of measurement: Enzymatic method.;Model-insulin resistance index (HOMA-IR). Timepoint: Before the intervention and twelve weeks after. Method of measurement: HOMA= fasting serum insulin (µU/ml)× fasting plasma glucose (mM/L)/22.5.;Body fat percentage. Timepoint: Before the intervention and twelve weeks after. Method of measurement: Bioelectrical Impedance Analysis (BIA). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactHedieh Rahmani
Ahvaz University of Medical Sciences
Outcome results
None listed