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Comparison of the efficacy of oral, intravenous and topical Tranexamic acid in reducing bleeding after total knee arthroplasty

Comparison of the efficacy of oral, intravenous and topical Tranexamic acid in reducing bleeding after total knee arthroplasty

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20180411039272N1
Enrollment
135
Registered
2018-06-10
Start date
2018-04-23
Completion date
Unknown
Last updated
2018-07-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Total knee arthroplasty. Unspecified complication of internal orthopaedic prosthetic device, implant and graft

Interventions

Intervention 1: Intervention group 1: We prescribe 10 milligram in kilogram Tranexamic acid by slow intravenous injection in first group. Intervention 2: Intervention group 2: We prescribe 2 gram Tran

Sponsors

Arak University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
30 Years to 80 Years

Inclusion criteria

Inclusion criteria: Patients undergoing total knee arthroplasty admitted in Amiralmoemenin and Valiasr hospital in Arak Patients between 30 and 80 years old Patient with ASA class1 and 2 Patients who have informed consent for presence in mentioned project Patients who are operated by one surgeon duration of operation time between 90 and 180 minutes

Exclusion criteria

Exclusion criteria: All Patients out rang of 30 to 80 years old Lack of Informed consent Patients with multiple surgeries Patients who are sensitive to Tranexamic acid Patients undergoing general anesthesia

Design outcomes

Primary

MeasureTime frame
Mean of bleeding in patients undergoing arthroplasty after operation. Timepoint: 4 and 24 and 48 hours after operation. Method of measurement: Millileter.;Mean of bleeding during of operation. Timepoint: During of operation. Method of measurement: Millileter.;Number of come back again of patients to operation room. Timepoint: 48 hours after operation. Method of measurement: Number.;Mean of hemoglobin. Timepoint: 4 and 24 and 48 hours after operation. Method of measurement: Milligram in millileter.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Hosseinali Hadi

Arak University of Medical Sciences

Hadi@arakmu.ac.ir+98 86 3417 3502

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026