Sepsis. Gram-negative sepsis, unspecified
Conditions
Interventions
Intervention 1: Intervention group: 25 patients will be received magnesium sulfate (2 g magnesium sulfate in 50 ml of normal saline over one hour) as intravenous infusion. Infusion of magnesium sulfat
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Critically ill adult patients (18-65 years old) admitted to ICU with diagnosis of sepsis will be included.
Exclusion criteria
Exclusion criteria: Exclusion criteria: Patients with hypermagnesemia (serum magnesium level> 3.5 mg/dL, hypomagnesemia (serum magnesium level<1.5 mg/dL), renal failure (GFR <30 ml/min /1.73 m2), moderate to severe hepatic insufficiency (child pugh score B, C), seizure , chronic alcohol consumption, malignancy, MAP <65 mm Hg resistant to vasopressors, diabetic ketoacidosis and pregnant women will be excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Lactate clearance. Timepoint: At the beginning of the study (before the intervention) and then every 6 hours on the day 0 - Day 1 - Day 2. Method of measurement: By spectrophotometry and Pars-Azmoon kit in mg/dl.;Serum magnesium level. Timepoint: At the beginning of the study (before the intervention) and then every 6 hours on the day 0 - Day 1 - Day 2. Method of measurement: By spectrophotometry and Pars-Azmoon kit in mg/dl.;Intracellular magnesium concentration (RBC magnesium level). Timepoint: At the beginning of the study (before the intervention) and then every 6 hours on the day 0 - Day 1 - Day 2. Method of measurement: By spectrophotometry and Pars-Azmoon kit in mg/dl. | — |
Secondary
| Measure | Time frame |
|---|---|
| SOFA score (Sepsis-related organ failure assessment score). Timepoint: At the beginning of the study (before the intervention), then daily on day 0 - day 1- day 2. Method of measurement: Based on the SOFA score scale.;APACHE II score ( Acute Physiologic And Chronic Health Evaluation ). Timepoint: At the beginning of the study (before the intervention), then daily on day 0 - day 1- day 2. Method of measurement: Based on the APACHE-II score scale.;Duration of intensive care unit stay. Timepoint: Daily. Method of measurement: Count the number of hospitalization days in the intensive care unit.;Mortality. Timepoint: Daily. Method of measurement: Count the number of dead patients. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactHossein Khalili
Tehran University of Medical Sciences
Outcome results
None listed