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comparing IVF results in two GnRH antagonist protocols and Stop protocol (GnRH agonist/antagonist) in patients with polycystic ovary syndrome

Clinical trial comparing IVF results in two GnRH antagonist protocols and Stop protocol (GnRH agonist/antagonist) in patients with polycystic ovary syndrome

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT20180409039247N8
Enrollment
60
Registered
2023-08-17
Start date
2023-08-23
Completion date
Unknown
Last updated
2023-08-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

infertility. Female infertility

Interventions

Intervention 1: Intervention group: In the GnRH group, Stop starts in the mid-luteal phase (previous cycle) and with the onset of menstruation on the 2nd-3rd day of the gonadotropin cycle, the dose of

Sponsors

Tehran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
20 Years to 35 Years

Inclusion criteria

Inclusion criteria: PCO patients according to Rotterdam criteria Age 20 to 35 years Infertility > 1 year Sperm analysis is normal or has the minimum necessary criteria for ICSI AMH above 5

Exclusion criteria

Exclusion criteria: History of autoimmune diseases, coagulation disorders, uterine anomalies, chromosomal and genetic disorders, chronic renal and metabolic diseases, hypo and hyperthyroidism, history of malignancy, endometriosis, history of repeated miscarriage and repeated implantation failure Pharmaceutical reaction to ovulation stimulation drugs Lack of follicle growth suitable for puncture The patient's lack of consent to complete the treatment course Severe Oligoastenoteratospermia

Design outcomes

Primary

MeasureTime frame
The number of follicles above 16 mm, the degree of follicle synchrony, the number and quality of obtained oocytes (metaphase 1, 2 and GV). Timepoint: The examination will be cross-sectional on the day of oocyte puncture. Method of measurement: Questionnaire for demographic information and patient records, ultrasound to check follicles and embryology laboratory information to check the number and quality of oocytes and embryos.

Secondary

MeasureTime frame
Number and quality of embryos. Timepoint: On the day of ovarian puncture. Method of measurement: It is determined by the embryologist three days after the puncture.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMarjan Ghaemi

Tehran University of Medical Sciences

marjan_ghaemi@yahoo.com+98 21 8800 4858

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026