Vaginal dryness. Menopausal and female climacteric states
Conditions
Interventions
Intervention 1: Intervention group 1: Fractional CO2 laser + Platelet-Rich Plasma (PRP) injection (4 sessions, 3-week intervals). Intervention 2: Intervention group:ntervention group 2: Fractional CO2
Sponsors
Tehran University of Medical Sciences - Research Assistant
Eligibility
Sex/Gender
Female
Age
40 Years to 60 Years
Inclusion criteria
Inclusion criteria: Vaginal dryness Vaginal burning Dyspareunia Dissatisfaction with topical estrogen treatment menopause
Exclusion criteria
Exclusion criteria: Drug addictionSmokingAlcohol consumption Hormone replacement therapy within the past 6 months Acute or recurrent genitourinary tract infection
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main outcome variable is the improvement of vaginal dryness symptoms, including dyspareunia, burning, libido, vulvar discomfort, discharge, urinary infections, and post-coital bleeding, assessed over one year of follow-up. Timepoint: Primary outcome variables will be assessed at baseline (before intervention), and then at 1 month, 3 months, 6 months, and 12 months after completion of the intervention sessions. Method of measurement: The primary outcome will be measured using the Vaginal Health Index Score (VHI) assessed by a blinded gynecologist and a Visual Analogue Scale (VAS) for patient-reported symptoms such as dryness and dyspareunia. These tools will be applied at baseline and repeated at 1, 3, 6, and 12 months after the intervention to evaluate efficacy and durability. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMarjan Ghaemibidgoli
Tehran University of Medical Sciences
Outcome results
None listed