infertility. Female infertility
Conditions
Interventions
Intervention 1: Intervention group: During laparoscopy, a 0.5 cm long electrocautery needle is used to create 7 holes in each ovary with a depth of 5 mm. Diathermy is performed with a cutting power of
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
20 Years to 38 Years
Inclusion criteria
Inclusion criteria: 1-Patients diagnosed with PCO according to Rotterdam criteria 2-Age 20 to 38 years old 3-Resistance to clomiphene (after three cycles up to 150 mg from day 5 to 9 of menstruation every month) Infertility for more than 12 months 4-Body mass index (BMI) less than 35 kg/m2
Exclusion criteria
Exclusion criteria: Other endocrine disorders such as hyperprolactinemia and thyroid dysfunction. Women with fallopian tube disease diagnosed by laparoscopy History of autoimmune diseases, coagulation disorders, uterine anomalies, chromosomal and genetic disorders, chronic renal and metabolic diseases, history of malignancy endometriosis history of repeated abortion and RIF
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Study of AMH changes before and after ovarian drilling. Timepoint: Comparison of laboratory criteria and patient symptoms before and 6 months after intervention. Method of measurement: lab test with PCR.;InhibinB changes before and after ovarian drilling. Timepoint: Comparison of laboratory criteria and patient symptoms before and 6 months after intervention. Method of measurement: lab test with PCR.;Study of improvement of menstrual cycle regularity before and after ovarian drilling. Timepoint: Menstrual cycle with history taking before and after intervention. Method of measurement: History Taking.;Study of improvement of hirsutism and acne before and after ovarian drilling. Timepoint: physical examination. Method of measurement: acne and hirsutism scoring.;Spontaneous pregnancy rate before and after ovarian drilling. Timepoint: bhcg checking after intervention. Method of measurement: serum beta hcg. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMarjan Ghaemi
Tehran University of Medical Sciences
Outcome results
None listed