female infertility. Female infertility
Conditions
Interventions
Intervention 1: Intervention group 1: Stop GnRH-ag/GnRH-ant regimen In the GnRH regimen, Stop agonist is started in the mid-luteal phase (previous cycle) and stopped with the onset of menstruation and
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
40 Years to 49 Years
Inclusion criteria
Inclusion criteria: POR patients according to the Bologna criteria: old age (40 years) or any other risk factor for POR such as endometriosis and ovarian surgery, autoimmune diseases and genetic problems Achieving =3 oocytes with the gnrh antagonist stimulation protocol in the previous cycle Abnormality of ovarian reserve tests (AFC<3-5, AMH<0.5-1.1 ng) in the absence of old age of the mother or abnormality of ovarian reserve BMI below 27 Sperm analysis is normal or has the minimum necessary criteria for ICSI
Exclusion criteria
Exclusion criteria: History Of Autoimmune Diseases, Coagulation Disorders, Uterine Anomalies, Chromosomal And Genetic Disorders, Chronic Renal And Metabolic Diseases, Hypo And Hyperthyroidism, History Of Malignancy, Endometriosis Recurrent Pregnancy Loss Recurrent Implantation Failure
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The number of follicles above 16 mm, the degree of SYNCHRONY of the follicles, the number and quality of the obtained oocytes (metaphase 1 and 2 and GV). Timepoint: The time to evaluate the results will be on the same day of oocyte retrieval. Method of measurement: Evaluations are performed in IVF lab and recorded by an embryologist. | — |
Secondary
| Measure | Time frame |
|---|---|
| The number and quality of embryos obtained - the total dose of gonadotropins used - and the final cost of treatment. Timepoint: The time to evaluate the results will be on the same day of oocyte puncture. Method of measurement: Evaluation is done by an embryologist. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMarjan Ghaemibidgoli
Tehran University of Medical Sciences
Outcome results
None listed