Comparison of Ringer and Ringer Lactate Solution on Acidose and Lactate Status in Pediatric Heart Surgery

Comparison of effect of ringer's solution and lactated ringer as prime solution on acidosis and lactate level in noncyanotic pediatric cardiac surgery

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20180407039222N1

Enrollment

Registered

2018-07-08

Start date

2018-07-06

Completion date

Unknown

Last updated

2018-09-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Metabolic Acidosis. Acidosis

Interventions

Intervention 1: Intervention group: In the first group, a lactate ringer solution will be used to prepare the cardiopulmonary bypass system.Also, the venofundin 6% etherified starch solution at 15 cc

Eligibility

Sex/Gender

All

Age

12 Months to 48 Months

Inclusion criteria

Inclusion criteria: Children with non-cyanotropic heart disease Having consent from the parents of the patient Non-emergency surgery Absence of coagulation disorders Absence of anemia (hemoglobin less than 10 g / dl) Absence of hepatic impairment Absence of kidney failure Absence of lung failure Absence of diabetes Absence of acid disorder and severe preoperative hypertension Lactate levels greater than 2 mM per liter before surgery Not having a history of heart surgery (redo) Age 12 to 48 months

Exclusion criteria

Exclusion criteria: Periods of arterial blood pressure reduction before surgery Ultrafiltration during bypass

Design outcomes

Primary

Measure	Time frame
PH level. Timepoint: Before the onset of cardiopulmonary bypass and during anesthesia, 5 minutes, 30 minutes and one hour after the onset of cardiopulmonary bypass. Method of measurement: Arterial blood sample and arterial gas analyzer.;Blood lactate level. Timepoint: Before the onset of cardiopulmonary bypass and during anesthesia, 5 minutes, 30 minutes and one hour after the onset of cardiopulmonary bypass. Method of measurement: Arterial blood samples and Care diagnostica machine.;Arterial blood bicarbonate level. Timepoint: Before the onset of cardiopulmonary bypass and during anesthesia, 5 minutes, 30 minutes and one hour after the onset of cardiopulmonary bypass. Method of measurement: Arterial blood sample and arterial gas analyzer.;Arterial base excess level. Timepoint: Before the onset of cardiopulmonary bypass and during anesthesia, 5 minutes, 30 minutes and one hour after the onset of cardiopulmonary bypass. Method of measurement: Arterial blood sample and arterial gas analyzer.;Arterial blood chloride level. Timepoint: Before the onset of cardiopulmonary bypass and during anesthesia, 5 minutes, 30 minutes and one hour after the onset of cardiopulmonary bypass. Method of measurement: Arterial blood sample and arterial gas analyzer.	—

Measure

Time frame

PH level. Timepoint: Before the onset of cardiopulmonary bypass and during anesthesia, 5 minutes, 30 minutes and one hour after the onset of cardiopulmonary bypass. Method of measurement: Arterial blood sample and arterial gas analyzer.;Blood lactate level. Timepoint: Before the onset of cardiopulmonary bypass and during anesthesia, 5 minutes, 30 minutes and one hour after the onset of cardiopulmonary bypass. Method of measurement: Arterial blood samples and Care diagnostica machine.;Arterial blood bicarbonate level. Timepoint: Before the onset of cardiopulmonary bypass and during anesthesia, 5 minutes, 30 minutes and one hour after the onset of cardiopulmonary bypass. Method of measurement: Arterial blood sample and arterial gas analyzer.;Arterial base excess level. Timepoint: Before the onset of cardiopulmonary bypass and during anesthesia, 5 minutes, 30 minutes and one hour after the onset of cardiopulmonary bypass. Method of measurement: Arterial blood sample and arterial gas analyzer.;Arterial blood chloride level. Timepoint: Before the onset of cardiopulmonary bypass and during anesthesia, 5 minutes, 30 minutes and one hour after the onset of cardiopulmonary bypass. Method of measurement: Arterial blood sample and arterial gas analyzer.

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Secondary

Measure	Time frame
The amount of sodium bicarbonate injected to correct acidosis. Timepoint: 5 minutes, 30 minutes and one hour after the start of the bypass. Method of measurement: observation.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDavood Samiei

Shahid Rajaee Cardiovascular Center

samdvd1979@yahoo.com+98 21 2392 2454

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026