Skip to content

The effectiveness of licorice solution in Recurrent Aphthous Stomatitis

Comparison of the effectiveness of Glycyrrhiza glabra solution with Diphenhydramine Elixir in the management of pain and duration of Recurrent Aphthous Stomatitis

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT20180407039213N1
Enrollment
70
Registered
2018-06-29
Start date
2018-06-20
Completion date
Unknown
Last updated
2018-07-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Recurrent Aphthous Stomatitis. Recurrent oral aphthae

Interventions

Intervention 1: Intervention group: Patients with RAS gargle licorice 5% in Diphenhydramine every 6 hours (3 ml for 3 minutes) until improvement. Intervention 2: Control group: RAS patients gargle Di

Sponsors

Birjand University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
15 Years to 40 Years

Inclusion criteria

Inclusion criteria: Patients with RAS symptoms for less than 1 day

Exclusion criteria

Exclusion criteria: The patients who did not sign the letter of informed consent Patient with hypertension (greater than 80/130) Use of systemic aphthous treatment (over the past three months) and topical treatment during the procedure Atypical aphthous cases and cases suspected of Behcet's syndrome, inflammatory bowel disease. Pregnant or lactating women Patients with Diabetes Patients with RAS symptoms for more than 1 day

Design outcomes

Primary

MeasureTime frame
Improvement of pain and duration of Recurrent Aphthous Stomatitis symptoms. Timepoint: Measurement of pain intensity and healing of wound in second, third, and fifth days of intervention. Method of measurement: Visual Analogue Scale (VAS) to measure pain and physical examination to detect wound healing.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAkbari Narjes

Birjand University of Medical Sciences

narges-akbare4021@yahoo.com+98 56 3239 5000

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 27, 2026