Effect of Tranexamic Acid on blood loss in Pelvic and Acetabular fractures

Effect of Intravenous Tranexamic Acid on blood loss in Pelvic and Acetabular fractures in patients referred to Taleghani and Emam Hosein Hospital of Tehran between 2019-2020

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20180404039188N2

Enrollment

108

Registered

2021-05-10

Start date

2019-03-21

Completion date

Unknown

Last updated

2021-05-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Fracture of acetabulum. Condition 2: Fracture of pelvis. Unspecified fracture of acetabulum Fracture of unspecified parts of lumbosacral spine and pelvis

Interventions

Intervention 1: Intervention group: Intervention group will receive 15 milligrams per kilogram intravenous tranexamic acid dissolved in 500 milliliters of normal saline 30 minutes prior to start of su

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients with pelvic fractures Patients with acetabular fractures

Exclusion criteria

Exclusion criteria: Age below 18

Design outcomes

Primary

Measure	Time frame
Estimated blood loss during surgery. Timepoint: End of surgery. Method of measurement: Estimated Blood Loss(in milliliter)=1000((hemoglobin level before sugery - hemoglobin after surgery) total body volume + transfused allogeneic hemoglobin).;Post-op drained blood. Timepoint: Last day of hospitalization. Method of measurement: Perception and by using drainage bag.	—

Secondary

Measure	Time frame
Vein thrombosis of lower limb. Timepoint: three months. Method of measurement: color doppler ultrasonography if patient has related symptoms.;Pulmonary embolism. Timepoint: three months. Method of measurement: Lung CT angiography if patient has related symptoms.;Drug-associated reaction. Timepoint: three months. Method of measurement: Questionnaire based on drug-associated reaction symptoms answered by patient.	—

Measure

Time frame

Vein thrombosis of lower limb. Timepoint: three months. Method of measurement: color doppler ultrasonography if patient has related symptoms.;Pulmonary embolism. Timepoint: three months. Method of measurement: Lung CT angiography if patient has related symptoms.;Drug-associated reaction. Timepoint: three months. Method of measurement: Questionnaire based on drug-associated reaction symptoms answered by patient.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactReza Zandi

Shahid Beheshti University of Medical Sciences

reza.zandi@sbmu.ac.ir+98 21 2303 1111

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026