Hemodynamic effects of 2% lidocaine with 1:100,000 epinephrine compared to 4% articaine with 1:100,000 epinephrine

Hemodynamic changes after administration of 2% lidocaine with 1:100,000 epinephrine compared to 4% articaine with 1:100,000 epinephrine: prospective, double-blinded, randomized clinical trial

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20180330039161N2

Enrollment

Registered

2019-08-04

Start date

2019-09-12

Completion date

Unknown

Last updated

2019-10-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Impacted mandibular third molar. Underdosing of dental drugs, topically applied, initial encounter

Interventions

Intervention 1: Intervention group: Patients candidate of surgical removal of mandibular third molar removal received two capules of 1.8 mg of 4% articaine with 1:100,000 epinephrine to anesthetize th

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: ASA 1 and 2 Level A and Class I Pell and Gregory classification of impacted mandibular third molars patients who weren’t diagnosed as hypertensive and their blood pressure <140/90 mm Hg

Exclusion criteria

Exclusion criteria: hypertension cardiovascular disease sickle cell anemia congenital methemoglobinemia pregnancy hyperthyroidism breastfeeding allergy to local anesthetics any contraindications to epinephrine if the extraction required more than 2 local anesthetic cartridges the duration exceeded 45 minutes

Design outcomes

Primary

Measure	Time frame
Hemodynamic change. Timepoint: Before surgery, after anesthetic injection, after surgical removal of the impacted third molars. Method of measurement: pulse oximetry, electronic sphygmomanometer.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSaeid Tavanafar

Shiraz University of Medical Sciences

tavanafar@sums.ac.ir+98 71 3230 6655

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026