medication related osteonecrosis of the jaw. Osteonecrosis due to drugs
Conditions
Interventions
Intervention group
the surgical protocol expected: 1) Chlorhexidine 0,2% mouthwashes 30 ml swished up to 60 seconds
2) local anesthesia achieved using 3% mepivacaine hydrochloride without adrenaline
3) elevation of a full-thickness mucoperiosteal flap
4) tooth luxation and avulsion were gently performed with elevators and forceps
5) if necessary, osteoplasty 6) debridement of the post-extraction socket with miller surgical curette and irrigation of the sockets with rifamycin sodium
7) application of a single dosage of autologous platelet-rich plasma (Plateltex ACT System ®, Biomed, Modena, IT)
8) tension-free soft tissue closure. To prepare the PRP and to induce its gelation, the materials provided by the manufacturer were used and the provided instructions followed [Mazzucco L, Balbo V, Ca
94(3):202-8.].
Sponsors
University of Palermo
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: metabolic bone disease and/or malignant tumors treatment with bisphosphonates because of the underlying disease required tooth extraction
Exclusion criteria
Exclusion criteria: clinical or radiological signs of medication related osteonecrosis of the jaw in the surgical area previous history of irradiation to the head and neck area neoplastic involvement of the jaws poor general conditions pregnant or breast-feeding women
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Absence of signs related to MRONJ (Healing). Timepoint: We scheduled follow-up visits to remove the suture seven days after surgery, and visited patients on the fifteenth day, and continued on month one, three, six and twelve. Method of measurement: Clinical and radiological signs. | — |
Countries
Italy
Contacts
Public ContactGiuseppina Campisi
University of Palermo
Outcome results
None listed