Bisphosphonates related osteonecrosis of the jaw. Osteonecrosis due to drugs
Conditions
Interventions
Intervention group
the surgical protocol consisted of: 1) elevation of a full-thickness mucoperiosteal flap to expose the surgical area
3) bony curettage (debridement) and sequestrectomy of the necrotic bone, whether required, using a Er,Cr:YSGG laser
4) application of autologous platelet rich plasma (PRP)
5) tension-free soft tissue closure.
Sponsors
None
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: age = 18 years cancer; treatment with BPs because of the underlying cancer
Exclusion criteria
Exclusion criteria: previous history of irradiation to the maxillofacial area neoplastic involvement of the jaws previous surgical treatment to the jaws poor general conditions
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Absence of clinical and radiological signs of BRONJ relapse (healing) or, in turn, the transition from a higher stage to a lower one (improvement). Timepoint: We scheduled follow-up visits to remove the suture seven days after surgery, and visited patients on the fifteenth day, and continued on month one, three, six and twelve. Method of measurement: Clinical and radiological signs. | — |
Countries
Italy
Contacts
Public ContactGiuseppina Campisi
University of Palermo
Outcome results
None listed