Effect of TSH Level on adverse Outcome of Pregnancy in Subclinical Hypothyroidism

The effect of using two subclinical hypothyroid treatment approaches during pregnancy on the adverse outcomes of pregnancy

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20180314039091N1

Enrollment

100

Registered

2018-05-21

Start date

2018-04-09

Completion date

Unknown

Last updated

2018-06-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Subclinical hypothyroidism. Subclinical iodine-deficiency hypothyroidism

Interventions

Intervention 1: Intervention group: Levothyroxine tablets are treated with at least 50 micrograms per day and continue throughout pregnancy until delivery. Patient pills are made by Iranian hormones c

Eligibility

Sex/Gender

Female

Age

15 Years to 45 Years

Inclusion criteria

Inclusion criteria: Pregnant women with TSH levels ranging from 2.5 to 9.3 in the first trimester of pregnancy and TSH levels between 3 to 1.4 in the second and third trimesters Their free T4 levels are within the normal range Thyroid size is normal in the examination, and the nodule or mass is not touched Pregnant women who do not have a history of thyroid disease Do not have a history of Pregnancy Loss. There is no history of thyroid surgery

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Pregnancy Loss. Timepoint: Until 20 weeks for abortion and until delivery for IUFD and Fetal Loss. Method of measurement: check list.;Eclampsia. Timepoint: During pregnancy care. Method of measurement: Sphygmomanometer.;Neonatal death. Timepoint: Delivery. Method of measurement: check list.;11/5000Showing translation for ????? ?????Translate instead ????? ?????Apgar lower. Timepoint: Delivery. Method of measurement: Apgar score.;Preterm Labour and Delivery. Timepoint: From 20 to 37 weeks of pregnancy. Method of measurement: Check list.;Intra Uterim Growth Restrection. Timepoint: During pregnancy. Method of measurement: Ultrasound.;Premature rupture of membranes. Timepoint: Third Trimsters Pregnancy. Method of measurement: Chek list.;Placenta previa - premature separation of pelacenta - abruptio placenta. Timepoint: Pregnancy. Method of measurement: Chek list.	—

Measure

Time frame

Pregnancy Loss. Timepoint: Until 20 weeks for abortion and until delivery for IUFD and Fetal Loss. Method of measurement: check list.;Eclampsia. Timepoint: During pregnancy care. Method of measurement: Sphygmomanometer.;Neonatal death. Timepoint: Delivery. Method of measurement: check list.;11/5000Showing translation for ????? ?????Translate instead ????? ?????Apgar lower. Timepoint: Delivery. Method of measurement: Apgar score.;Preterm Labour and Delivery. Timepoint: From 20 to 37 weeks of pregnancy. Method of measurement: Check list.;Intra Uterim Growth Restrection. Timepoint: During pregnancy. Method of measurement: Ultrasound.;Premature rupture of membranes. Timepoint: Third Trimsters Pregnancy. Method of measurement: Chek list.;Placenta previa - premature separation of pelacenta - abruptio placenta. Timepoint: Pregnancy. Method of measurement: Chek list.

—

Secondary

Measure	Time frame
Thyroid hormones(FT4 - T4 - TSH - TOP Ab). Timepoint: Until the 20th of every month and then at week 32 to 36. Method of measurement: T4 and TSH (ECL method) FT4 and TPO Ab (ICMA method).	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFarahnaz Mir

Zanjan University of Medical Sciences

dr.Fa_Mir@zums.ac.ir+98 24 3377 0814

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026