Colorectal cancer. Malignant neoplasm of colon, unspecified
Conditions
Interventions
Intervention 1: Intervention 1: a 50000 IU vitamin D perl, weekly+ 2 omega-3 fatty acid capsules, daily. Intervention 2: Intervention group 2: a 50000 IU vitamin D perl, weekly+ 2 omega-3 fatty acid p
Sponsors
Ahvaz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Patients with stage ?? or ??? colorectal cancer if they have to begin chemotherapy; Aged 18 years or more; BMI range of 18.5-30 kg/m2; Serum 25(OH)D < 30 ng/ml; Not having autoimmune disease, diabetes, hypertension, renal, hepatic, parathyroid, and gastrointestinal disorders; No taking vitamin D and/or omeaga-3 supplements and other vitamin- mineral supplements or parenteral nutrition; Not taking laxative, anti-inflammatory and blood thinner medications; Absence of allergic to fish and fish products, and history of having other cancers.
Exclusion criteria
Exclusion criteria: Affecting by any acute disease during the study; Changing the drug regimen; refusing to continue the chemotherapy; Unwilling to continue the study; Patients who had less than 90% compliance with treatment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum level of TNF-a. Timepoint: Before and 8 weeks after intervention. Method of measurement: Serum TNF-a levels will be assessed by ELISA and Bender Med kit (Bender Med, Germany). | — |
Secondary
| Measure | Time frame |
|---|---|
| Tumor marker CEA. Timepoint: Before and 8 weeks after intervention. Method of measurement: Tumor marker CEA will be assessed by ELISA and CanAg kit (CanAg, Italy). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Fatemeh Haidari
Ahvaz University of Medical Sciences
Outcome results
None listed