Mannitol efficacy in ovarian hyper stimulation syndrome

Efficacy Assessment of Mannitol vs Albumin in Management of Ovarian Hyperstimulation Syndrome – A randomized controlled trial

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20180305038953N1

Enrollment

Registered

2018-05-15

Start date

2017-03-21

Completion date

Unknown

Last updated

2018-06-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ovarian hyper stimulation syndrome. Hyperstimulation of ovaries

Interventions

Intervention 1: Intervention group: Intravenous infusion of 500 ml Mannitol 20% at the same time with 500 ml Glucose 5% using y-site over 4 hours daily or twice a day a (based on clinical responses).

Eligibility

Sex/Gender

Female

Age

20 Years to 40 Years

Inclusion criteria

Inclusion criteria: Severe ovarian htper stimulation syndrome

Exclusion criteria

Exclusion criteria: Patient dissatisfaction to participate in the study History of / sensitivity to the used drug

Design outcomes

Primary

Measure	Time frame
Abdominal girth. Timepoint: Every morning. Method of measurement: Centimeter.;Weight. Timepoint: Every morning. Method of measurement: Digital scale; kilogram.;Hematocrite. Timepoint: Every 8 to 24 hours based on clinical severity of symptoms. Method of measurement: Colormetry; Percent.;Serum creatinine. Timepoint: Every 8 to 24 hours based on clinical severity of symptoms. Method of measurement: Milligram/deciliter.;Serum sodium level. Timepoint: Every 8 to 24 hours based on clinical severity of symptoms. Method of measurement: Ion Selective Electrode (ISE); millimol/milliliter.;Serum potassium level. Timepoint: Every 8 to 24 hours based on clinical severity of symptoms. Method of measurement: Ion Selective Electrode (ISE); millimol/milliliter.	—

Measure

Time frame

Abdominal girth. Timepoint: Every morning. Method of measurement: Centimeter.;Weight. Timepoint: Every morning. Method of measurement: Digital scale; kilogram.;Hematocrite. Timepoint: Every 8 to 24 hours based on clinical severity of symptoms. Method of measurement: Colormetry; Percent.;Serum creatinine. Timepoint: Every 8 to 24 hours based on clinical severity of symptoms. Method of measurement: Milligram/deciliter.;Serum sodium level. Timepoint: Every 8 to 24 hours based on clinical severity of symptoms. Method of measurement: Ion Selective Electrode (ISE); millimol/milliliter.;Serum potassium level. Timepoint: Every 8 to 24 hours based on clinical severity of symptoms. Method of measurement: Ion Selective Electrode (ISE); millimol/milliliter.

—

Secondary

Measure	Time frame
Duration of hospitalization. Timepoint: At the end of hospitalization. Method of measurement: Number of days.;Total cost of medicine used. Timepoint: At the end of drug therapy. Method of measurement: Total cost of medicine in Rials.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMaryam Namdar Khanzedeh

sarem Fertility and Infertility Research Center (SAFIR)

dr.m_namdar@saremcrc.com+98 21 4467 0883

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026