Effectiveness of progesterone, Duphaston, and placebo to prevent preterm birth

Effectiveness of progesterone, Duphaston, and placebo to increase gastaional age in preterm labor

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20180303038922N1

Enrollment

300

Registered

2018-03-17

Start date

2018-04-04

Completion date

Unknown

Last updated

2018-03-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Preterm labor. Preterm labor

Interventions

Intervention 1: Intervention group: Duphaston group. Intervention 2: Intervention group: progesterone group. Intervention 3: Control group: No intervention.

Eligibility

Sex/Gender

Female

Age

18 Years to 37 Years

Inclusion criteria

Inclusion criteria: Gestational age between 24-34 weeks Maternal age between 18-37 years old Singleton pregnancy Contractions occur one to eight minutes apart. Dilatation less than 3 cm. Effacement less than 80 percent intact amniotic membrane

Exclusion criteria

Exclusion criteria: Maternal or fetal conditions that necessitate urgent delivery fetal anomalies Evidence for tocolytic drug contraindication Allergy to progestrone

Design outcomes

Primary

Measure	Time frame
Uterine contractions. Timepoint: every 2 weeks until 36 weeks and then weekly. Method of measurement: Uterine contractions are measured by Cardiotachometer.	—

Secondary

Measure	Time frame
Gestational age at labor. Timepoint: every 2 weeks until 36 weeks and then weekly. Method of measurement: gestational age in weeks (based on first trimester ultrasound).	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMarzieh Lotfalizadeh

Mashhad University of Medical Sciences

LotfalizadeM@mums.ac.ir+98 51 3854 3031

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026