Efficacy of Mannitol on the success rate of anesthesia in mandibular posterior teeth

Aneasthetic success of Articaine\Epinephrine with combination of Mannitol in comparison with Articaine\Epinephrine for inferior alveolar nerve block in patients with symptomatic irreversible pulpitis: A randomized controlled clinical trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20180228038901N1

Enrollment

124

Registered

2018-04-30

Start date

2018-04-04

Completion date

Unknown

Last updated

2018-05-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Symptomatic irreversible pulpitis. Pulpitis

Interventions

Intervention 1: Intervention group1:IANB(Inferior alveolar nerve block) standard injection using Articaine 4% solution(DENTACAIN,Exir,Iran ) will be done . After 15 minutes of block anesthesia and n

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: patients without relevant medical conditions patients older than 18 Patients not taking beta-blockers patients not being medicated with any opioids preoperatively patients without drug abusing No pregnant or nursing mothers Those without a contraindication for the use of Mannitol Those known not to be allergic to one of the study medications Those without orofacial infection

Exclusion criteria

Exclusion criteria: subjects with negative response to cold testing Teeth with periradicular disease(unlike a widened periodontal ligament)

Design outcomes

Primary

Measure	Time frame
The amount of pain. Timepoint: During access cavity preparation and entrance in to the pulp chamber and the root canal. Method of measurement: Using Visual Analog Scale.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSahar Shakouei

Dental and Periodontal Research Center

sshakouie@hotmail.com+98 41 3335 5965

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026