"Evaluation if weight bearing exercises on patients with knee osteoarthritis treated by stromal cells"

Evaluation of weight bearing exercises on pain and physical function of patients with knee osteoarthritis treated by implantation of autologous bone marrow derived mesenchymal stromal cells.

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20180226038870N2

Enrollment

Registered

2021-03-11

Start date

2021-01-20

Completion date

Unknown

Last updated

2021-04-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Knee Osteoarthritis. Osteoarthritis of knee

Interventions

Intervention 1: Intervention group: In the group receiving exercises with weight bearing (group A), the exercise sessions are as follows: Aerobic exercises include: walking 3 days a week with moderate

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Knee osteoarthritis of grade 2 or 3 diagnosed by MRI and confirmed by orthopedics surgeon. Less than one month before enrollment in the present study, the patient underwent intra-knee implantation of bone marrow-derived mesenchymal stromal cells. Aged between 18-65 years old.

Exclusion criteria

Exclusion criteria: Uncontrolled medical situations which need frequent medical treatment and therefore patient will be unable regularly participate in follow up sessions of current trial, such as cancers and autoimmune diseases. Pregnancy and lactating

Design outcomes

Primary

Measure	Time frame
Pain on Visual Analogue Scale. Timepoint: Measurement of patients' pain in the knee joint according to Visual Analogue Scale criteria before the intervention and 1 month and 3 months after the intervention. Method of measurement: Pain on Visual Analogue Scale.	—

Secondary

Measure	Time frame
Patients physical function based on Western Ontario and McMaster Universities Osteoarthritis Index. Timepoint: Before intervention and 1 and 3 months after intervention. Method of measurement: Using Western Ontario and McMaster Universities Osteoarthritis Index questionnaire.;Patient walking distance. Timepoint: Before intervention and 1 and 3 months after intervention. Method of measurement: Based on the patient interview.;Standing time. Timepoint: Before intervention and 1 and 3 months after intervention. Method of measurement: Based on the patient interview.;Patient quality of life. Timepoint: Before intervention and 1 and 3 months after intervention. Method of measurement: The 36-Item Short Form Survey (SF-36).	—

Measure

Time frame

Patients physical function based on Western Ontario and McMaster Universities Osteoarthritis Index. Timepoint: Before intervention and 1 and 3 months after intervention. Method of measurement: Using Western Ontario and McMaster Universities Osteoarthritis Index questionnaire.;Patient walking distance. Timepoint: Before intervention and 1 and 3 months after intervention. Method of measurement: Based on the patient interview.;Standing time. Timepoint: Before intervention and 1 and 3 months after intervention. Method of measurement: Based on the patient interview.;Patient quality of life. Timepoint: Before intervention and 1 and 3 months after intervention. Method of measurement: The 36-Item Short Form Survey (SF-36).

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammad Hassabi

Shahid Beheshti University of Medical Sciences

ddrnlz@gmail.com+98 21 2243 2560

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026