epithelial carcinoma of head and neck. Malignant neoplasms of lip, oral cavity and pharynx
Conditions
Interventions
Intervention 1: Intervention group: weekly schedules of cisplatin. Intervention 2: Control group: three weekly schedule of cisplatin.
Sponsors
Shahid Beheshti University of Medical Sciences
Eligibility
Sex/Gender
All
Age
20 Years to 75 Years
Inclusion criteria
Inclusion criteria: histologically proven malignancy in resected specimen all epithelial carcinoma of head and neck that needs concurrent chemoraradiation stages 3,4 of the disease aged 20-75 years old ECOG Performance Status :0-2 no prior radiation therapy or chemotherapy adequate organ function written informed consent
Exclusion criteria
Exclusion criteria: active multiple primary cancers; synchronous or metachronous within 5 years infection requiring systemic treatment women who are or may be pregnant psychosis or psychiatric symptoms/signs that judged to male participation in the study difficult uncontrolled diabetes mellitus uncontrolled hypertension
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Lymphocyte. Timepoint: weekly. Method of measurement: blood serum level.;Neutrophil. Timepoint: weekly. Method of measurement: blood serum level.;Hemoglobin. Timepoint: weekly. Method of measurement: blood serum level.;Platelet. Timepoint: weekly. Method of measurement: blood serum level.;Creatinin. Timepoint: weekly. Method of measurement: blood serum level.;Leukocyte. Timepoint: weekly. Method of measurement: blood serum level. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public Contactshokoufe Norouzi
Shahid Beheshti University of Medical Sciences
Outcome results
None listed