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Effect of doxycycline on Crestal Bone Resorption

Study of the preventive effect of doxycycline at the abutment-implant interface on crestal bone resorption and peri-implant mucositis: a randomized controlled clinical trials

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20180222038827N2
Enrollment
20
Registered
2018-06-02
Start date
2011-04-30
Completion date
Unknown
Last updated
2018-07-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: peri-implant mucositis. Condition 2: crestal bone loss. Post-osseointegration biological failure of dental implant Post-osseointegration biological failure of dental implant

Interventions

Intervention 1: Intervention group: a half of mouth is intervention group
Doxycycline polymer with trade name of Atridox was placed in annulus space in the final prosthesis delivery time and before closing abutment screw
the evaluation of probing depth, bleeding on probing and the distance of fixture shoulder and crest of bone was done 3, 6 and 9 months after the delivery of finally prothesis. Intervention 2: Contro
No drug use in Annulous space
the evaluation of probing depth, bleeding on probing and the distance of fixture shoulder and crest of bone was done 3, 6 and 9 months after the delivery of finally prothesis.

Sponsors

Tehran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: People with at least 2 implantium implants (Dentium, Seoul, South Korea) The site of implant in the area of first and second premolar

Exclusion criteria

Exclusion criteria: Systemic diseases that influence on bone such as; diabetes, renal diseases and osteoporosis Smoking. Periodontal diseases Attached gingival under 2 mm Poor hygiene

Design outcomes

Primary

MeasureTime frame
Bleeding on probing. Timepoint: 3, 6 and 12 months after the delivery of final prosthesis. Method of measurement: periodontal probe.;Probing depth in mesial and distal of implant. Timepoint: 3, 6 and 12 months after the delivery of final prosthesis. Method of measurement: periodontal prob.;The measurement of fixture shoulder to the bone crest. Timepoint: 3, 6 and 12 months after the delivery of final prosthesis. Method of measurement: periapical radiography.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMahnaz

Tehran University of Medical Sciences

mahnazarshad@yahoo.com+98 21 2227 3471

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026