Effect of 360-degree tissue ring in treatment of keratoconus

Corneal tissue augmentation in advanced keratoconus using Corneal allogenic intrastromal 360 degree ring segments combined with accelerated collagen cross linking

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20180217038768N2

Enrollment

Registered

2025-05-12

Start date

2025-05-15

Completion date

Unknown

Last updated

2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Keratoconus. Keratoconus

Interventions

Intervention group: The Dsek lenticules available in the operating room will be used to create a 360-degree tissue ring with a thickness of 300 microns and an inner diameter of 4 and an outer diameter

Eligibility

Sex/Gender

All

Age

25 Years to 40 Years

Inclusion criteria

Inclusion criteria: Patients aged 25 to 40 years old with advanced keratoconus Patients with contact lens intolerance Patients with an increase in K Max or K steep of more than 0.75 diopters over the past 6 months Having consent to participate in the study at every stage of the study

Exclusion criteria

Exclusion criteria: Patients with a history of previous corneal and intraocular surgery Patients with central or paracentral corneal scars Patients with a history of viral keratitis Patients with central corneal thickness less than 400 microns Patients with severe allergies or immunodeficiency and autoimmune syndromes

Design outcomes

Primary

Measure	Time frame
Corneal steep keratometry. Timepoint: Before the intervention, 6 and 12 months after the surgical intervention. Method of measurement: Pentacam imaging.;Corneal astigmatism. Timepoint: Before the intervention, 6 and 12 months after the surgical intervention. Method of measurement: Pentacam imaging.;Corneal thickness. Timepoint: Before the intervention, 6 and 12 months after the surgical intervention. Method of measurement: Anterior segment Optical Coherence Tomography.;Uncorrected distance visual acuity. Timepoint: Before the intervention, 6 and 12 months after the surgical intervention. Method of measurement: Snellen chart.;Corrected distance visual acuity. Timepoint: Before the intervention, 6 and 12 months after the surgical intervention. Method of measurement: Snellen chart.	—

Measure

Time frame

Corneal steep keratometry. Timepoint: Before the intervention, 6 and 12 months after the surgical intervention. Method of measurement: Pentacam imaging.;Corneal astigmatism. Timepoint: Before the intervention, 6 and 12 months after the surgical intervention. Method of measurement: Pentacam imaging.;Corneal thickness. Timepoint: Before the intervention, 6 and 12 months after the surgical intervention. Method of measurement: Anterior segment Optical Coherence Tomography.;Uncorrected distance visual acuity. Timepoint: Before the intervention, 6 and 12 months after the surgical intervention. Method of measurement: Snellen chart.;Corrected distance visual acuity. Timepoint: Before the intervention, 6 and 12 months after the surgical intervention. Method of measurement: Snellen chart.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactJaber Mohseni

Tehran University of Medical Sciences

dr.jaber1369@gmail.com+98 21 5540 0011

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026