A survey of the effect of ozonated water mouthwash on oral health and incidence of ventilator-associated pneumonia in patients connected to mechanical ventilation

A survey of the effect of ozonated water mouthwash on oral health and incidence of ventilator-associated pneumonia in patients connected to mechanical ventilation in intensive care units - A randomized clinical trial

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20180213038720N2

Enrollment

Registered

2019-12-18

Start date

2019-09-23

Completion date

Unknown

Last updated

2020-05-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: ventilator-associated pneumonia. Condition 2: oral health. Air conditioner and humidifier lung

Interventions

Intervention 1: Intervention group: Firstly, inner surface of the mouth is thoroughly washed using a soft brush (for kids) on which 0.5 cm of fluoride-rich toothpaste is applied followed by a suction

Eligibility

Sex/Gender

All

Age

15 Years to 85 Years

Inclusion criteria

Inclusion criteria: Availability of tracheal tube and connecting to the mechanical ventilation machine within no more than 24 hours from the intubation of the patient and connection to the machine. No oral wounds or injuries No engagement with immunosuppressive diseases No record or symptoms of aspiration No coagulation abnormalities No dentures No engagement with the asthma No allergy and nose/mouth inflammation No record of radiotherapy treatment No use of antibiotic mouthwash during the past two months No pregnancy NO symptoms of pulmonary infection

Exclusion criteria

Exclusion criteria: any allergic response to brushing, Toothpaste and any of the mouthwashes the patient’s first-order relative(s) dissatisfaction with the study.

Design outcomes

Primary

Measure	Time frame
Oral health. Timepoint: Every other day. Method of measurement: Beck Oral Assessment Scale (BOAS), Mucosal Plaque Score (MPS).;Incidence of ventilator-associated pneumonia. Timepoint: Before the intervention and after the intervention. Method of measurement: Clinical Pulmonary Infection Score (CPIS), Cultivation of pharynx.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMostafa Soodmand

Rasht University of Medical Sciences

msudmand@yahoo.com+98 13 3355 5056

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026