The effect of dexamethasone and endonestrone premedication on the incidence of nausea and vomiting after cesarean section

A comparative study of the effects of Dexamethasone and Ondansetron on nausea and vomiting in cesarean section under spinal anesthesia by Bupivacaine (Marcaine)

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20180210038681N1

Enrollment

120

Registered

2018-05-01

Start date

2018-01-29

Completion date

Unknown

Last updated

2018-05-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

nausea and vomiting.

Interventions

Intervention 1: Intervention group (1) used single bolus dose of Dexamethasone (8 mg ) simultaneously with prep and drep, after spinal anesthesia with bupivacaine (0.5% ) and spinal needle 25 gauge.

Eligibility

Sex/Gender

Female

Age

15 Years to 45 Years

Inclusion criteria

Inclusion criteria: All patients who have attended for elective cesarean section In the ASA class one and two being in fertility age Patients with normal, mild or moderate stress, anxiety and depression level Patients who will undergo spinal anesthesia with bupivacaine 0.5%

Exclusion criteria

Exclusion criteria: Patients suffering from pregnancy toxicity ( eclampsia- preclampsia) or history of motion sickness, history of meniere disease, and migraine BMI greater than 40 history of PONV( post opreative neusea and vomiting ) severe or very severe level Stress , anxiety and depression Cigarette smoking and opoid drug consumption Patients that donot to cooperate Patients who undergo spinal anesthesia with lidocaine 5% Patients who receive atropine during opreation

Design outcomes

Primary

Measure	Time frame
Nausea. Timepoint: In PACU (at 0 oclock) and 2 oclock and after 6 oclock, the incidence of nausea and vomiting in the patient. Method of measurement: VAS ( Visual analog scale ).;Vomiting. Timepoint: At PACU (at the begining) and 2 hours and 6 hours later. Method of measurement: Interview with patient.;Stress, depression and anxiety. Timepoint: In the recovery before surgery. Method of measurement: Depression‚ Anxiety‚ Stress Scale (DASS).	—

Measure

Time frame

Nausea. Timepoint: In PACU (at 0 oclock) and 2 oclock and after 6 oclock, the incidence of nausea and vomiting in the patient. Method of measurement: VAS ( Visual analog scale ).;Vomiting. Timepoint: At PACU (at the begining) and 2 hours and 6 hours later. Method of measurement: Interview with patient.;Stress, depression and anxiety. Timepoint: In the recovery before surgery. Method of measurement: Depression‚ Anxiety‚ Stress Scale (DASS).

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactJahanbahsh rezanejadei

Khoram-Abad University of Medical Sciences

rezanezhdi.j@lums.ac.ir+98 66 3342 0030

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026