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The effect of chlorhexidine mouthwash and combined mouthwash (4 drugs) in the prevention and treatment of oral mucositis in neutropenic patients

Comparison of the effect of chlorhexidine mouthwash and combined mouthwash (4 drugs) in the prevention and treatment of oral mucositis in neutropenic patients hospitalized in the pediatric oncology department of Shahid Sadoughi hospital, Yazd.

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20180209038673N8
Enrollment
60
Registered
2024-07-19
Start date
2024-07-22
Completion date
Unknown
Last updated
2024-07-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute lymphoblastic leukemia. Acute lymphoblastic leukemia, in relapse

Interventions

Intervention 1: Intervention group: Group 1 patients receive 0.2% chlorhexidine mouthwash twice a day for 1 month. Intervention 2: Intervention group: group 2 patients receive a combined mouthwash (c

Sponsors

Yazd University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
2 Years to 18 Years

Inclusion criteria

Inclusion criteria: Patients with ALL undergoing chemotherapy with the same treatment protocol Patients with neutropenia without oral mucositis Hospitalized patients in Shahid Sadoughi hospital

Exclusion criteria

Exclusion criteria: Lack of consent of the patient's parents

Design outcomes

Primary

MeasureTime frame
Severity of mucositis. Timepoint: Oral intervention will be carried out for at least 1 month and twice a day, and patients will be clinically examined by a pediatric oncology specialist every week. Method of measurement: Mucositis grading criteria (grade 0 to 4) according to WHO.

Secondary

MeasureTime frame
Pain severity. Timepoint: Oral intervention will be carried out for at least 1 month and twice a day, and patients will be clinically examined by a pediatric oncology specialist every week. Method of measurement: Using VAS score.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMotahare Taghvaei

Yazd University of Medical Sciences

motahare.taghvaei73@gmail.com+98 35 3822 8000

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026