Rheum palmatum root in systolic heart failure

Clinical trial of the effect of "Rheum palmatum root"on quality of life in patients with systolic heart failure

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20180206038645N1

Enrollment

Registered

2018-03-05

Start date

2018-04-04

Completion date

Unknown

Last updated

2018-03-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Systolic heart failure. Systolic (congestive) heart failure

Interventions

Intervention 1: Intervention group: Dry extract of Rheum palmatum root with a concentration of 10% relative to 100 gr of roots of the plant, has been standardized 250mg per capsule at the school of ph

Eligibility

Sex/Gender

All

Age

40 Years to 75 Years

Inclusion criteria

Inclusion criteria: Informed study participation Age 40 to 75 Systolic heart failure with ejection fraction equal or lesser than 40 percent Continuing heart medications prescribed by cardiologist

Exclusion criteria

Exclusion criteria: Pregnancy Breast feeding Malignancy Hypersensivity to rheum palmatum root Unwillingness of the patient to continue coperation Chronic Inflamatory diseas Severe Renal failure Collagen vascular disease Sever liver disease Acute infectious disease De compensated heart failure

Design outcomes

Primary

Measure	Time frame
Quality of Life Score in the Minnesota Questionnaire. Timepoint: Measure the quality of life score at the beginning of study(before intervention)and one week after taking the Rheum Palmatum Root Extract. Method of measurement: Minnesota Living With Heart Failure Questionnaire.;The distance traveled in six minute walk test. Timepoint: Measure the distance traveled in six minute walk test at the beagining of study(before intervention)and one week after taking the Rheum Palmatum Root Extract. Method of measurement: Six minute walk test.	—

Measure

Time frame

Quality of Life Score in the Minnesota Questionnaire. Timepoint: Measure the quality of life score at the beginning of study(before intervention)and one week after taking the Rheum Palmatum Root Extract. Method of measurement: Minnesota Living With Heart Failure Questionnaire.;The distance traveled in six minute walk test. Timepoint: Measure the distance traveled in six minute walk test at the beagining of study(before intervention)and one week after taking the Rheum Palmatum Root Extract. Method of measurement: Six minute walk test.

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Secondary

Measure	Time frame
Left ventricular ejection fraction. Timepoint: Measurement of left ventricular ejection fraction at the beginning of study (before intervention). Method of measurement: Ecocardiography.;Complete blood count. Timepoint: Measurement of complete blood count at the begining of study(before intervention)and one week after taking Rheum Palmatum Root Extract. Method of measurement: Blood test.;Cr. Timepoint: Measurement of creatinine at the beginning of study (be a for intervention) and one week after taking Rheum palmatum root extract. Method of measurement: Blood test.;ALT. Timepoint: Measurement of Alanin Aminotransfers at the beginning of first study (be a for intervention) and one week after taking Rheum palmatum root extract. Method of measurement: Blood test.;AST. Timepoint: Measurement of Aspartat Aminotransferas at the begining first study (be a for intervention) and one week after taking Rheum palmatum root extract. Method of measurement: Blood test.;CRP. Timepoint: Measurement of C_Reactive Protein at the beginning of first study (be a for intervention) and one week after taking Rheum palmatum extract. Method of measurement: Blood test.;ALKP. Timepoint: Measurement of Alkaline phosphatas at the beginning of study (be a for intervention) and one week after taking Rheum palmatum extract. Method of measurement: Blood test.	—

Measure

Time frame

Left ventricular ejection fraction. Timepoint: Measurement of left ventricular ejection fraction at the beginning of study (before intervention). Method of measurement: Ecocardiography.;Complete blood count. Timepoint: Measurement of complete blood count at the begining of study(before intervention)and one week after taking Rheum Palmatum Root Extract. Method of measurement: Blood test.;Cr. Timepoint: Measurement of creatinine at the beginning of study (be a for intervention) and one week after taking Rheum palmatum root extract. Method of measurement: Blood test.;ALT. Timepoint: Measurement of Alanin Aminotransfers at the beginning of first study (be a for intervention) and one week after taking Rheum palmatum root extract. Method of measurement: Blood test.;AST. Timepoint: Measurement of Aspartat Aminotransferas at the begining first study (be a for intervention) and one week after taking Rheum palmatum root extract. Method of measurement: Blood test.;CRP. Timepoint: Measurement of C_Reactive Protein at the beginning of first study (be a for intervention) and one week after taking Rheum palmatum extract. Method of measurement: Blood test.;ALKP. Timepoint: Measurement of Alkaline phosphatas at the beginning of study (be a for intervention) and one week after taking Rheum palmatum extract. Method of measurement: Blood test.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactZohre Gholami

Zanjan University of Medical Sciences

gholami1393@zums.ac.ir+98 24 3377 0801

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026