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The effect of midazolam on headache

The effect of midazolam on prevention of post dural puncture headache

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20180205038631N1
Enrollment
120
Registered
2019-09-29
Start date
2018-05-20
Completion date
Unknown
Last updated
2019-11-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Post dural puncture headache. Other reaction to spinal and lumbar puncture

Interventions

Intervention 1: Intervention group: 3 milligram midazolam diluted in normal saline and volume of 5 milliliter was injected intravenously five minutes before dural puncture in single dose. Intervention

Sponsors

Ahvaz University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Undergoing diagnostic lumbar puncture for any indication 18 to 60 years old

Exclusion criteria

Exclusion criteria: Any known chronic pulmonary disease Known sensitivity to benzodiazepines Decreased level of consciousness or other conditions that the patient is unable to tell us about his headache. Pregnancy

Design outcomes

Primary

MeasureTime frame
Incidence of post dural puncture headache. Timepoint: This evaluation was performed at 6, 12, 24, 48, 72 and on the fourth and fifth days after lumbar puncture. Method of measurement: Diagnostic criteria of the International Classification of Headache Disorders, third edition (beta version).;The severity of post dural puncture headache. Timepoint: This evaluation was performed at 6, 12, 24, 48, 72 and on the fourth and fifth days after lumbar puncture. Method of measurement: Visual Analogue Scale.;The duration of post dural puncture headache. Timepoint: This evaluation was performed at 6, 12, 24, 48, 72 and on the fourth and fifth days after lumbar puncture. Method of measurement: Daily headache diary.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDavood Kashipazha

Ahvaz University of Medical Sciences

dakashi47@gmail.com+98 61 3374 3012

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026