Ankle sprain. Sprain of ankle
Conditions
Interventions
Intervention 1: Intervention group: Blind Platelet-rich plasma(PRP)+exercise therapy. Intervention 2: Control group: Exercise therapy.
Sponsors
Iran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Informed consent Age between 18 and 60 years At least 3 months of similar pain At least one episode of ankle giving-way after an initial sprain Grade 2 anterior talofibular ligament (ATFL) injury (incomplete ligament tear, partial loss of functional mobility, and mild to moderate joint instability) and Grade 3 injury (complete ligament tear, inability to bear weight or significant joint instability, in which the patient’s pain decreases with initial conservative treatments including relative rest, cryotherapy, bandaging, elevation, and immobilization). VAS score greater than 4
Exclusion criteria
Exclusion criteria: Musculoskeletal disorders (e.g., genu varum/valgum, flatfoot, high arches) History of ankle surgery or trauma Steroid injection or other interventions within past 6 months Pregnancy History of Diabetes Mellitus History of cancer Occurrence of a severe complication resulting from the injection Participant withdrawal Ankle pathologies such as cellulitis, cuts, bruises, osteomyelitis, deformities Known rheumatologic diseases (e.g., RA) Anterior talofibular ligament (ATFL) injury requiring surgical intervention (complete ligament tear, inability to bear weight, or significant joint instability in which the patient’s pain does not improve with initial conservative treatments including relative rest, cryotherapy, bandaging, elevation, and immobilization, or when the patient prefers surgical treatment). Inability of the participant to complete follow-up assessments
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The severity of pain. Timepoint: Zero, one month, 3 months, six months after. Method of measurement: Visual Analog Scale (VAS).;Function of ankle in daily life and sport activities according to FAAM questionnaire. Timepoint: Zero, one month, 3 months, six months after. Method of measurement: Foot and Ankle Ability Measure (FAAM) questionnaire.;Results of Biodex System which is in Firoozgar hospital. Timepoint: Zero, one month, 3 months, six months after. Method of measurement: Biodex Balance system. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactKatayoun Moradi
Iran University of Medical Sciences
Outcome results
None listed