The effect of preoperative and postoperative vitamin D medication therapy on postoperative urinary IL18,KIM1levels in modarres hospital CABG patients in 1397 year

The association between vitamin D medication therapy and reducing post coronary bypass graft surgery acute kidney injury in patients with low vitamin D levels.

Status

Recruiting

Phases

Phase 1

Study type

Interventional

Source

IRCT

Registry ID

IRCT20180131038578N1

Enrollment

Registered

2019-03-20

Start date

2019-01-21

Completion date

Unknown

Last updated

2019-03-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Post coronary artery bypass graft surgery acute kidney injury. Postprocedural (acute) (chronic) kidney failure

Interventions

Intervention 1: Intervention group: is going to be prescribed 50000 units vitamin D for 3 consecutive days , 3 times a day. vitamin D level ,IL18,KIM1is going to be measured before the surgery.IL18,K

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: CABG surgery for the first time. The patient who had just CABG surgery without another surgery at the same time, like valvular replacement. CPB usage in the surgery. Patients with vitamin D level less than 20 ng/ml.

Exclusion criteria

Exclusion criteria: Taking vitamin D supplements before the study. ESRD or cr level more than 1.5 mg/dl Taking nephrotoxic drugs. Less than 3 days gap between angiography and surgery.

Design outcomes

Primary

Measure	Time frame
The renal injury marker urinary level interlukin-18. Timepoint: Before the surgery, in no time after surgery , a day after surgery. Method of measurement: The enzyme-linked immunosorbent assay (ELISA).;The renal injury marker urinary level,kidney injury molecule-1. Timepoint: Before the surgery, in no time after surgery , a day after surgery. Method of measurement: The enzyme-linked immunosorbent assay (ELISA).	—

Measure

Time frame

The renal injury marker urinary level interlukin-18. Timepoint: Before the surgery, in no time after surgery , a day after surgery. Method of measurement: The enzyme-linked immunosorbent assay (ELISA).;The renal injury marker urinary level,kidney injury molecule-1. Timepoint: Before the surgery, in no time after surgery , a day after surgery. Method of measurement: The enzyme-linked immunosorbent assay (ELISA).

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Secondary

Measure	Time frame
Creatinine serum levels . Timepoint: In no time before the surgery, after surgery and the day after surgery. Method of measurement: Laboratory test for creatinine.;Bleeding . Timepoint: In no time , 6 hours , 12 hours after surgery 2. Method of measurement: Collected by chest tube by ML/Hour.;Ventilation . Timepoint: During 12 hours after CABG surgery. Method of measurement: Ventilator for ventilation measuring by per hour.;Packed RBC cell transfusion . Timepoint: During 12 hours after CABG surgery . Method of measurement: packed RBC cell bag for transfusion.	—

Measure

Time frame

Creatinine serum levels . Timepoint: In no time before the surgery, after surgery and the day after surgery. Method of measurement: Laboratory test for creatinine.;Bleeding . Timepoint: In no time , 6 hours , 12 hours after surgery 2. Method of measurement: Collected by chest tube by ML/Hour.;Ventilation . Timepoint: During 12 hours after CABG surgery. Method of measurement: Ventilator for ventilation measuring by per hour.;Packed RBC cell transfusion . Timepoint: During 12 hours after CABG surgery . Method of measurement: packed RBC cell bag for transfusion.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMahnoosh Foroughi

Shahid Beheshti University of Medical Sciences

Mahnoosh.foroughi@gmail.com+98 21 2207 4087

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026