Biebersteinia Multifida root in systolic heart failure

Clinical trial of the effect of “Biebersteinia Multifida root” on quality of life in patients with systolic heart failure

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20180130038565N1

Enrollment

Registered

2018-02-19

Start date

2018-03-01

Completion date

Unknown

Last updated

2018-03-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Systolic heart failure. Systolic (congestive) heart failure

Interventions

Intervention 1: Intervention group: Dry extract of Biebersteinia Multifida root with a concentration of 10 percent relative to 100 g of roots of the plant, has been standardized 250 mg per capsule at

Eligibility

Sex/Gender

All

Age

40 Years to 75 Years

Inclusion criteria

Inclusion criteria: Informed consent to participate in the study Age 40 to 75 Systolic heart failure with ejection fraction equal or lesser than 40 percent Continuing heart medications, prescribed by cardiologist

Exclusion criteria

Exclusion criteria: Pregnancy Breast feeding Malignancy Allergy to Biebersteinia Multifida root extract Unwillingness of the patient to continue cooperation Chronic inflammatory disease Severe renal failure Collagen vascular disease Severe liver disease Acute infectious disease Decompensated heart failure

Design outcomes

Primary

Measure	Time frame
Quality of Life Score in the Minnesota Questionnaire. Timepoint: Measure the quality of life score at the beginning of study (before intervention) and one week after taking the Biebersteinia Multifida root extract. Method of measurement: Minnesota Living With Heart Failure Questionnaire.;The distance traveled in six minute walk test. Timepoint: Measure the distance traveled in six minute walk test at the beginning of study (before intervention) and one week after taking the Biebersteinia Multifida root extract. Method of measurement: Six minute walk test.	—

Measure

Time frame

Quality of Life Score in the Minnesota Questionnaire. Timepoint: Measure the quality of life score at the beginning of study (before intervention) and one week after taking the Biebersteinia Multifida root extract. Method of measurement: Minnesota Living With Heart Failure Questionnaire.;The distance traveled in six minute walk test. Timepoint: Measure the distance traveled in six minute walk test at the beginning of study (before intervention) and one week after taking the Biebersteinia Multifida root extract. Method of measurement: Six minute walk test.

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Secondary

Measure	Time frame
Left ventricular ejection fraction. Timepoint: Measurement of left ventricular ejection fraction at the beginning of study (before intervention). Method of measurement: Echocardiography.;Complete blood count. Timepoint: Measurement of complete blood count at the beginning of study (before intervention) and one week after taking the Biebersteinia Multifida Root Extract. Method of measurement: Blood test.;Blood urea nitrogen. Timepoint: Measurement of blood urea nitrogen at the beginning of study (before intervention) and one week after taking the Biebersteinia Multifida Root Extract. Method of measurement: Blood test.;Serum creatinine. Timepoint: Measurement of serum creatinine at the beginning of study (before intervention) and one week after taking the Biebersteinia Multifida Root Extract. Method of measurement: Blood test.;Alanine aminotransferase. Timepoint: Measurement of Alanine aminotransferase at the beginning of study (before intervention) and one week after taking the Biebersteinia Multifida Root Extract. Method of measurement: Blood test.;Aspartate aminotransferase. Timepoint: Measurement of Aspartate aminotransferase at the beginning of study (before intervention) and one week after taking the Biebersteinia Multifida Root Extract. Method of measurement: Blood test.;Alkaline phosphatase. Timepoint: Measurement of Alkaline phosphatase at the beginning of study (before intervention) and one week after taking the Biebersteinia Multifida Root Extract. Method of measurement: Blood test.;C-reactive protein. Timepoint: Measurement of C-reactive protein at the beginning of study (before intervention) and one week after taking the Biebersteinia Multifida Root Extract. Method of measurement: Blood test.	—

Measure

Time frame

Left ventricular ejection fraction. Timepoint: Measurement of left ventricular ejection fraction at the beginning of study (before intervention). Method of measurement: Echocardiography.;Complete blood count. Timepoint: Measurement of complete blood count at the beginning of study (before intervention) and one week after taking the Biebersteinia Multifida Root Extract. Method of measurement: Blood test.;Blood urea nitrogen. Timepoint: Measurement of blood urea nitrogen at the beginning of study (before intervention) and one week after taking the Biebersteinia Multifida Root Extract. Method of measurement: Blood test.;Serum creatinine. Timepoint: Measurement of serum creatinine at the beginning of study (before intervention) and one week after taking the Biebersteinia Multifida Root Extract. Method of measurement: Blood test.;Alanine aminotransferase. Timepoint: Measurement of Alanine aminotransferase at the beginning of study (before intervention) and one week after taking the Biebersteinia Multifida Root Extract. Method of measurement: Blood test.;Aspartate aminotransferase. Timepoint: Measurement of Aspartate aminotransferase at the beginning of study (before intervention) and one week after taking the Biebersteinia Multifida Root Extract. Method of measurement: Blood test.;Alkaline phosphatase. Timepoint: Measurement of Alkaline phosphatase at the beginning of study (before intervention) and one week after taking the Biebersteinia Multifida Root Extract. Method of measurement: Blood test.;C-reactive protein. Timepoint: Measurement of C-reactive protein at the beginning of study (before intervention) and one week after taking the Biebersteinia Multifida Root Extract. Method of measurement: Blood test.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactEbadollah Salekmoghadam

Zanjan University of Medical Sciences

salekmoghadam@zums.ac.ir+98 24 3377 0801

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026