Effect of Centaurea behen Root in Systolic Heart Failure

Clinical Trial of the Centaurea behen Root Effect on Quality of Life in Patients with Systolic Heart Failure

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20180130038563N1

Enrollment

Registered

2018-02-21

Start date

2018-03-01

Completion date

Unknown

Last updated

2018-03-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Systolic heart failure. Systolic (congestive) heart failure

Interventions

Intervention 1: Intervention group: A Centaurea behen root extract, with a concentration of 20 percent from plant root and as capsules with a dose of 150 milligrams of dried extract that has been stan

Eligibility

Sex/Gender

All

Age

40 Years to 75 Years

Inclusion criteria

Inclusion criteria: Informed study participation Age 40 to 75 Systolic heart failure with ejection fraction equal or lesser than 40 percent Currently taking heart medications, prescribed by cardiologist

Exclusion criteria

Exclusion criteria: Pregnancy Breast feeding Allergy to Centaurea behen root extract Patient's unwillingness to continue participation Chronic inflammatory disease Severe renal failure Collagen vascular disease Severe liver disease Acute infectious disease Malignancy Decompensated heart failure

Design outcomes

Primary

Measure	Time frame
The Quality of Life Score in the Minnesota Questionnaire. Timepoint: At the beginning of the study (before intervention) and one week after the end of the Centaurea behen Root Extract taking. Method of measurement: The Minnesota Living with Heart Failure Questionnaire.;The Distance traveled in The Six Minute Walk Test. Timepoint: At the beginning of the study (before intervention) and one week after the end of the Centaurea behen Root Extract taking. Method of measurement: The Six Minute Walk Test.	—

Measure

Time frame

The Quality of Life Score in the Minnesota Questionnaire. Timepoint: At the beginning of the study (before intervention) and one week after the end of the Centaurea behen Root Extract taking. Method of measurement: The Minnesota Living with Heart Failure Questionnaire.;The Distance traveled in The Six Minute Walk Test. Timepoint: At the beginning of the study (before intervention) and one week after the end of the Centaurea behen Root Extract taking. Method of measurement: The Six Minute Walk Test.

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Secondary

Measure	Time frame
The Left Ventricular Ejection Fraction. Timepoint: At the beginning of the study (before intervention). Method of measurement: Echocardiography.;Complete blood count. Timepoint: At the beginning of the study (before intervention) and one week after the end of the Centaurea behen Root Extract taking. Method of measurement: Blood test.;Blood urea nitrogen. Timepoint: At the beginning of the study (before intervention) and one week after the end of the Centaurea behen Root Extract taking. Method of measurement: Blood test.;C-reactive protein. Timepoint: At the beginning of the study (before intervention) and one week after the end of the Centaurea behen Root Extract taking. Method of measurement: Blood test.;Serum creatinine. Timepoint: At the beginning of the study (before intervention) and one week after the end of the Centaurea behen Root Extract taking. Method of measurement: Blood test.;Aspartate aminotransferase. Timepoint: At the beginning of the study (before intervention) and one week after the end of the Centaurea behen Root Extract taking. Method of measurement: Blood test.;Alanine aminotransferase. Timepoint: At the beginning of the study (before intervention) and one week after the end of the Centaurea behen Root Extract taking. Method of measurement: Blood test.;Alkaline phosphatase. Timepoint: At the beginning of the study (before intervention) and one week after the end of the Centaurea behen Root Extract taking. Method of measurement: Blood test.	—

Measure

Time frame

The Left Ventricular Ejection Fraction. Timepoint: At the beginning of the study (before intervention). Method of measurement: Echocardiography.;Complete blood count. Timepoint: At the beginning of the study (before intervention) and one week after the end of the Centaurea behen Root Extract taking. Method of measurement: Blood test.;Blood urea nitrogen. Timepoint: At the beginning of the study (before intervention) and one week after the end of the Centaurea behen Root Extract taking. Method of measurement: Blood test.;C-reactive protein. Timepoint: At the beginning of the study (before intervention) and one week after the end of the Centaurea behen Root Extract taking. Method of measurement: Blood test.;Serum creatinine. Timepoint: At the beginning of the study (before intervention) and one week after the end of the Centaurea behen Root Extract taking. Method of measurement: Blood test.;Aspartate aminotransferase. Timepoint: At the beginning of the study (before intervention) and one week after the end of the Centaurea behen Root Extract taking. Method of measurement: Blood test.;Alanine aminotransferase. Timepoint: At the beginning of the study (before intervention) and one week after the end of the Centaurea behen Root Extract taking. Method of measurement: Blood test.;Alkaline phosphatase. Timepoint: At the beginning of the study (before intervention) and one week after the end of the Centaurea behen Root Extract taking. Method of measurement: Blood test.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactSaeid Yousefi

Zanjan University of Medical Sciences

sayusefi@zums.ac.ir+98 24 3377 0801

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026