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Sperm selection by cumulus column

Investigating sperm parameters, DNA integrity, embryo cytokinetic and pregnancy rate from sperms selected by cumulus column compared to the control group in male factor infertile couples.

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20180130038561N2
Enrollment
100
Registered
2023-09-03
Start date
2023-10-23
Completion date
Unknown
Last updated
2023-10-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Male infertility. Azoospermia NOS Oligospermia NOS

Interventions

Intervention 1: Intervention group: The sperm selected for injection have passed through the cumulus column. Intervention 2: Control group: The sperm selected for injection prepared with the density g

Sponsors

Yazd University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
No minimum to 38 Years

Inclusion criteria

Inclusion criteria: Infertility couples with a male factor without varicocele diagnosis (at least one of the three sperm parameters outside the normal values ??defined by WHO) and a normal woman based on regular cycles, normal hysterosalpingogram, normal vaginal ultrasound, age under 38 years Estradiol level below 3000 and the presence of at least 3 follicles with a size > 14 on the trigger day Referring to the first or second cycle(s) of ICSI Having at least 6 mature MII oocytes for ICSI Male age less than 45 years

Exclusion criteria

Exclusion criteria: Male patients with severe male factor according to WHO criteria Frozen sperm sample Sperm sample obtained by aspiration or extraction from the testis HIV positive patients PCOS and endometriosis patients Patients at risk of OHSS

Design outcomes

Primary

MeasureTime frame
Chemical pregnancy. Timepoint: 2 weeks after embryo transfer. Method of measurement: Beta hCG test.

Secondary

MeasureTime frame
Differences in oocyte quality between individuals. Timepoint: The quality of oocyte is checked after puncture and before in vitro fertilization. Method of measurement: Grading based on standard criteria.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Esmat Mangoli

Yazd University of Medical Sciences

es.mangoli@gmail.com+98 35 3824 7085

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026