Reduction of agitation associated with ketamine

Comparing the effect of intravenous midazolam and oral melatonin on controlling agitation caused by ketamine in emergency department

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20180129038549N8

Enrollment

Registered

2018-09-24

Start date

2017-06-22

Completion date

Unknown

Last updated

2018-10-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Agitation. Restlessness and agitation

Interventions

Intervention 1: Intervention group 1: In this group patients are receiving 0.05 mg/kg intravenous midazolam (slow infusion) and one placebo tablet, 30 minutes before receiving ketamine as an anesthesi

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Age over 18 years old Receiving ketamine as an anesthetic agent for small surgeries Patient's consent to participate in the study

Exclusion criteria

Exclusion criteria: Fever Obesity (BMI>30) Head trauma with loss of consciousness Brain tumor, Hydrocephaly Glaucoma Psychosis Psychological disorders History of using Benzodiazepine during last two weeks

Design outcomes

Primary

Measure	Time frame
Richmond Agitation Scale score. Timepoint: Every 5 minutes after ketamine administration. Method of measurement: Richmond Agitation Scale table.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMehdi Botshekan

Esfahan University of Medical Sciences

saeedmajidinejad@yahoo.com+98 31 3668 0048

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026